Signe T Andersen1, Kasper Grosen2, Hatice Tankisi3, Morten Charles1, Niels T Andersen4, Henning Andersen5, Ioannis N Petropoulos6, Rayaz A Malik6, Troels S Jensen2, Pall Karlsson7. 1. Research Unit for General Practice & Section for General Medical Practice, Department of Public Health, Aarhus University, Aarhus, Denmark. 2. Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. 3. Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark. 4. Department of Public Health, Section for Biostatistics, Aarhus University, Aarhus, Denmark. 5. Department of Neurology, Aarhus University Hospital, Aarhus, Denmark. 6. Weill Cornell Medicine-Qatar, Education City, Doha, Qatar; Central Manchester University Hospitals Foundation Trust, Manchester, UK. 7. Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: pall@clin.au.dk.
Abstract
AIMS: In this cross-sectional study, we explored the utility of corneal confocal microscopy (CCM) measures for detecting diabetic polyneuropathy (DPN) and their association with clinical variables, in a cohort with type 2 diabetes. METHODS: CCM, nerve conduction studies, and assessment of symptoms and clinical deficits of DPN were undertaken in 144 participants with type 2 diabetes and 25 controls. DPN was defined according to the Toronto criteria for confirmed DPN. RESULTS: Corneal nerve fiber density (CNFD) was lower both in participants with confirmed DPN (n = 27) and in participants without confirmed DPN (n = 117) compared with controls (P = 0.04 and P = 0.01, respectively). No differences were observed for CNFD (P = 0.98) between participants with and without DPN. There were no differences in CNFL and CNBD between groups (P = 0.06 and P = 0.29, respectively). CNFD was associated with age, height, total- and LDL cholesterol. CONCLUSIONS: CCM could not distinguish patients with and without neuropathy, but CNFD was lower in patients with type 2 diabetes compared to controls. Age may influence the level of CCM measures.
AIMS: In this cross-sectional study, we explored the utility of corneal confocal microscopy (CCM) measures for detecting diabetic polyneuropathy (DPN) and their association with clinical variables, in a cohort with type 2 diabetes. METHODS: CCM, nerve conduction studies, and assessment of symptoms and clinical deficits of DPN were undertaken in 144 participants with type 2 diabetes and 25 controls. DPN was defined according to the Toronto criteria for confirmed DPN. RESULTS: Corneal nerve fiber density (CNFD) was lower both in participants with confirmed DPN (n = 27) and in participants without confirmed DPN (n = 117) compared with controls (P = 0.04 and P = 0.01, respectively). No differences were observed for CNFD (P = 0.98) between participants with and without DPN. There were no differences in CNFL and CNBD between groups (P = 0.06 and P = 0.29, respectively). CNFD was associated with age, height, total- and LDL cholesterol. CONCLUSIONS: CCM could not distinguish patients with and without neuropathy, but CNFD was lower in patients with type 2 diabetes compared to controls. Age may influence the level of CCM measures.
Authors: Troels S Jensen; Pall Karlsson; Sandra S Gylfadottir; Signe T Andersen; David L Bennett; Hatice Tankisi; Nanna B Finnerup; Astrid J Terkelsen; Karolina Khan; Andreas C Themistocleous; Alexander G Kristensen; Mustapha Itani; Søren H Sindrup; Henning Andersen; Morten Charles; Eva L Feldman; Brian C Callaghan Journal: Brain Date: 2021-07-28 Impact factor: 13.501
Authors: Varo Kirthi; Anugraha Perumbalath; Emily Brown; Sarah Nevitt; Ioannis N Petropoulos; Jamie Burgess; Rebecca Roylance; Daniel J Cuthbertson; Timothy L Jackson; Rayaz A Malik; Uazman Alam Journal: BMJ Open Diabetes Res Care Date: 2021-05
Authors: Ellen L Schaldemose; Rasmus E Hammer; Maryam Ferdousi; Rayaz A Malik; Jens R Nyengaard; Páll Karlsson Journal: Sci Rep Date: 2020-07-28 Impact factor: 4.379
Authors: Bruce A Perkins; Leif Erik Lovblom; Evan J H Lewis; Vera Bril; Maryam Ferdousi; Andrej Orszag; Katie Edwards; Nicola Pritchard; Anthony Russell; Cirous Dehghani; Danièle Pacaud; Kenneth Romanchuk; Jean K Mah; Maria Jeziorska; Andrew Marshall; Roni M Shtein; Rodica Pop-Busui; Stephen I Lentz; Mitra Tavakoli; Andrew J M Boulton; Nathan Efron; Rayaz A Malik Journal: Diabetes Care Date: 2021-07-01 Impact factor: 17.152
Authors: Maryam Ferdousi; Alise Kalteniece; Shazli Azmi; Ioannis N Petropoulos; Georgios Ponirakis; Uazman Alam; Omar Asghar; Andrew Marshall; Catherine Fullwood; Maria Jeziorska; Caroline Abbott; Giuseppe Lauria; Catharina G Faber; Handrean Soran; Nathan Efron; Andrew J M Boulton; Rayaz A Malik Journal: Diabetes Care Date: 2020-11-03 Impact factor: 19.112