Literature DB >> 30308467

Understanding molecular mechanisms of disease through spatial proteomics.

Sandra Pankow1, Salvador Martínez-Bartolomé1, Casimir Bamberger1, John R Yates2.   

Abstract

Mammalian cells are organized into different compartments that separate and facilitate physiological processes by providing specialized local environments and allowing different, otherwise incompatible biological processes to be carried out simultaneously. Proteins are targeted to these subcellular locations where they fulfill specialized, compartment-specific functions. Spatial proteomics aims to localize and quantify proteins within subcellular structures.
Copyright © 2018 Elsevier Ltd. All rights reserved.

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Year:  2018        PMID： 30308467      PMCID： PMC6435883          DOI： 10.1016/j.cbpa.2018.09.016

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  68 in total

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8.  Predicting subcellular localization of proteins based on their N-terminal amino acid sequence.

Authors:  O Emanuelsson; H Nielsen; S Brunak; G von Heijne
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9.  Improved sub-cellular resolution via simultaneous analysis of organelle proteomics data across varied experimental conditions.

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10.  Nuclear F-actin and myosins drive relocalization of heterochromatic breaks.

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4.  TRANSPIRE: A Computational Pipeline to Elucidate Intracellular Protein Movements from Spatial Proteomics Data Sets.

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7.  Proteomic analysis of the IPF mesenchymal progenitor cell nuclear proteome identifies abnormalities in key nodal proteins that underlie their fibrogenic phenotype.

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  7 in total

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