Literature DB >> 3030808

The human preproapolipoprotein C-II gene. Complete nucleic acid sequence and genomic organization.

S S Fojo, S W Law, H B Brewer.   

Abstract

The complete nucleic acid sequence of human preproapolipoprotein (apo) C-II has been determined from 2 apoC-II clones isolated from 2 different human genomic DNA libraries. The cloned fragments were approx. 14 and 18 kb long, and sequence analysis established that the apoC-II gene consists of 3338 nucleotides containing 3 intervening sequences of 2391, 167, and 298 bases. The first intron is located within the 5'-untranslated region of apoC-II and contains 4 Alu type sequences. The second intron interrupts the codon specifying amino acid - 11 of the apoC-II signal peptide. The last intron, which contains a 38 bp sequence which is repeated 6 times, interrupts the codon specifying for amino acid +44 of the mature apolipoprotein.

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Year:  1987        PMID： 3030808     DOI： 10.1016/0014-5793(87)81495-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  A polymorphic PstI site in intron 2 of the human apolipoprotein C-II gene detected by polymerase chain reaction.

Authors:  B R Zysow; C R Pullinger; J P Kane
Journal:  Hum Genet       Date:  1992-05       Impact factor: 4.132

2.  ETS target genes: identification of egr1 as a target by RNA differential display and whole genome PCR techniques.

Authors:  L Robinson; A Panayiotakis; T S Papas; I Kola; A Seth
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-08       Impact factor: 11.205

3.  Simple human DNA-repeats associated with genomic hypervariability, flanking the genomic retroposons and similar to retroviral sites.

Authors:  E I Rogaev
Journal:  Nucleic Acids Res       Date:  1990-04-11       Impact factor: 16.971

4.  Use of variable simple sequence motifs as genetic markers: application to study of myotonic dystrophy.

Authors:  H J Smeets; H G Brunner; H H Ropers; B Wieringa
Journal:  Hum Genet       Date:  1989-10       Impact factor: 4.132

5.  A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency.

Authors:  S S Fojo; P Lohse; C Parrott; G Baggio; C Gabelli; F Thomas; J Hoffman; H B Brewer
Journal:  J Clin Invest       Date:  1989-10       Impact factor: 14.808

6.  The 5' splice site: phylogenetic evolution and variable geometry of association with U1RNA.

Authors:  M Jacob; H Gallinaro
Journal:  Nucleic Acids Res       Date:  1989-03-25       Impact factor: 16.971

7.  A physical map of the apolipoprotein gene cluster on human chromosome 19.

Authors:  O Myklebost; S Rogne
Journal:  Hum Genet       Date:  1988-03       Impact factor: 4.132

8.  Donor splice site mutation in the apolipoprotein (Apo) C-II gene (Apo C-IIHamburg) of a patient with Apo C-II deficiency.

Authors:  S S Fojo; U Beisiegel; U Beil; K Higuchi; M Bojanovski; R E Gregg; H Greten; H B Brewer
Journal:  J Clin Invest       Date:  1988-11       Impact factor: 14.808

9.  Apo C-II deficiency type Bari.

Authors:  A Capurso; F Resta; F Turturro; A M Colacicco; C Crecchio; G Pepe
Journal:  Eur J Epidemiol       Date:  1992-05       Impact factor: 8.082

10.  Electrophoretic screening for human apolipoprotein C-II variants: repeated identification of apolipoprotein C-II(K19T).

Authors:  H Wiebusch; J R Nofer; A von Eckardstein; H Funke; U Wahrburg; H Martin; E Köhler; G Assmann
Journal:  J Mol Med (Berl)       Date:  1995-07       Impact factor: 4.599
  10 in total

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