| Literature DB >> 3030748 |
A Rietveld, T J van Kemenade, T Hak, A J Verkleij, B de Kruijff.
Abstract
The effect of cytochrome c oxidase incorporation on the lipid polymorphism of the cardiolipin-Ca2+ system was investigated by 31P NMR and freeze-fracture electron microscopy. The integral membrane protein has a stabilizing effect on the bilayer organization of cardiolipin, in that it inhibits the Ca2+-induced HII phase formation of this lipid for Ca2+/cardiolipin molar ratios of 1-10. At a Ca2+/cardiolipin molar ratio of 25, about 80% of the lipid is organized in the HII phase and a structural phase separation occurs between the cardiolipin-Ca2+ complex organized in the hexagonal HII phase without protein and bilayer structures with incorporated protein.Entities:
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Year: 1987 PMID： 3030748 DOI： 10.1111/j.1432-1033.1987.tb11004.x
Source DB: PubMed Journal: Eur J Biochem ISSN： 0014-2956