Carine W Maurer1, Kathrin LaFaver2, Gaurang S Limachia2, Geanna Capitan2, Rezvan Ameli2, Stephen Sinclair2, Steven A Epstein2, Mark Hallett2, Silvina G Horovitz2. 1. From the Human Motor Control Section, Medical Neurology Branch (C.W.M., K.L., G.S.L., G.C., M.H., S.G.H.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; Department of Neurology (C.W.M.), Stony Brook University School of Medicine, NY; Department of Neurology (K.L.), University of Louisville, KY; Experimental Therapeutics and Pathophysiology Branch (R.A.) and Office of the Clinical Director (S.S.), National Institute of Mental Health, NIH, Bethesda, MD; and Department of Psychiatry (S.A.E.), Georgetown University, Washington, DC. carine.maurer@stonybrookmedicine.edu. 2. From the Human Motor Control Section, Medical Neurology Branch (C.W.M., K.L., G.S.L., G.C., M.H., S.G.H.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; Department of Neurology (C.W.M.), Stony Brook University School of Medicine, NY; Department of Neurology (K.L.), University of Louisville, KY; Experimental Therapeutics and Pathophysiology Branch (R.A.) and Office of the Clinical Director (S.S.), National Institute of Mental Health, NIH, Bethesda, MD; and Department of Psychiatry (S.A.E.), Georgetown University, Washington, DC.
Abstract
OBJECTIVE: To explore alterations in gray matter volume in patients with functional movement disorders. METHODS: We obtained T1-weighted MRI on 48 patients with clinically definite functional movement disorders, a subset of functional neurologic symptom disorder characterized by abnormal involuntary movements, and on 55 age- and sex-matched healthy controls. We compared between-group differences in gray matter volume using voxel-based morphometry across the whole brain. All participants in addition underwent a thorough neuropsychological battery, including the Hamilton Anxiety and Depression Scales and the Childhood Trauma Questionnaire. To determine whether confounding factors such as comorbid depression, anxiety, or childhood trauma exposure contributed to the observed structural changes, nonparametric correlation analysis was performed. RESULTS: Patients with functional movement disorders exhibited increased volume of the left amygdala, left striatum, left cerebellum, left fusiform gyrus, and bilateral thalamus, and decreased volume of the left sensorimotor cortex (whole-brain corrected p ≤ 0.05). Volumetric differences did not correlate with measures of disease duration or patient-rated disease severity. CONCLUSION: This study demonstrates that patients with functional movement disorders exhibit structural gray matter abnormalities in critical components of the limbic and sensorimotor circuitry. These abnormalities may represent a premorbid trait rendering patients more susceptible to disease, the disease itself, or a compensatory response to disease.
OBJECTIVE: To explore alterations in gray matter volume in patients with functional movement disorders. METHODS: We obtained T1-weighted MRI on 48 patients with clinically definite functional movement disorders, a subset of functional neurologic symptom disorder characterized by abnormal involuntary movements, and on 55 age- and sex-matched healthy controls. We compared between-group differences in gray matter volume using voxel-based morphometry across the whole brain. All participants in addition underwent a thorough neuropsychological battery, including the Hamilton Anxiety and Depression Scales and the Childhood Trauma Questionnaire. To determine whether confounding factors such as comorbid depression, anxiety, or childhood trauma exposure contributed to the observed structural changes, nonparametric correlation analysis was performed. RESULTS:Patients with functional movement disorders exhibited increased volume of the left amygdala, left striatum, left cerebellum, left fusiform gyrus, and bilateral thalamus, and decreased volume of the left sensorimotor cortex (whole-brain corrected p ≤ 0.05). Volumetric differences did not correlate with measures of disease duration or patient-rated disease severity. CONCLUSION: This study demonstrates that patients with functional movement disorders exhibit structural gray matter abnormalities in critical components of the limbic and sensorimotor circuitry. These abnormalities may represent a premorbid trait rendering patients more susceptible to disease, the disease itself, or a compensatory response to disease.
Authors: J Stone; A Carson; R Duncan; R Roberts; C Warlow; C Hibberd; R Coleman; R Cull; G Murray; A Pelosi; J Cavanagh; K Matthews; R Goldbeck; R Smyth; J Walker; M Sharpe Journal: Clin Neurol Neurosurg Date: 2010-06-19 Impact factor: 1.876
Authors: Stephen M Smith; Mark Jenkinson; Mark W Woolrich; Christian F Beckmann; Timothy E J Behrens; Heidi Johansen-Berg; Peter R Bannister; Marilena De Luca; Ivana Drobnjak; David E Flitney; Rami K Niazy; James Saunders; John Vickers; Yongyue Zhang; Nicola De Stefano; J Michael Brady; Paul M Matthews Journal: Neuroimage Date: 2004 Impact factor: 6.556
Authors: David L Perez; Benjamin Williams; Nassim Matin; W Curt LaFrance; Victor Costumero-Ramos; Gregory L Fricchione; Jorge Sepulcre; Matcheri S Keshavan; Bradford C Dickerson Journal: J Neurol Neurosurg Psychiatry Date: 2017-08-26 Impact factor: 10.154
Authors: D P Bernstein; L Fink; L Handelsman; J Foote; M Lovejoy; K Wenzel; E Sapareto; J Ruggiero Journal: Am J Psychiatry Date: 1994-08 Impact factor: 18.112
Authors: Steven A Epstein; Carine W Maurer; Kathrin LaFaver; Rezvan Ameli; Stephen Sinclair; Mark Hallett Journal: Psychosomatics Date: 2016-04-29 Impact factor: 2.386
Authors: David L Perez; Timothy R Nicholson; Ali A Asadi-Pooya; Indrit Bègue; Matthew Butler; Alan J Carson; Anthony S David; Quinton Deeley; Ibai Diez; Mark J Edwards; Alberto J Espay; Jeannette M Gelauff; Mark Hallett; Silvina G Horovitz; Johannes Jungilligens; Richard A A Kanaan; Marina A J Tijssen; Kasia Kozlowska; Kathrin LaFaver; W Curt LaFrance; Sarah C Lidstone; Ramesh S Marapin; Carine W Maurer; Mandana Modirrousta; Antje A T S Reinders; Petr Sojka; Jeffrey P Staab; Jon Stone; Jerzy P Szaflarski; Selma Aybek Journal: Neuroimage Clin Date: 2021-03-11 Impact factor: 4.881