Literature DB >> 30303773

The Difference δ-Cells Make in Glucose Control.

Mark O Huising1,2, Talitha van der Meulen1, Jessica L Huang1, Mohammad S Pourhosseinzadeh1, Glyn M Noguchi1.   

Abstract

The role of beta and α-cells to glucose control are established, but the physiological role of δ-cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to modulate insulin and glucagon secretion at their source. We review the evidence for a negative feedback loop between delta and β-cells that determines the blood glucose set point and suggest that local δ-cell-mediated feedback stabilizes glycemic control.

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Year:  2018        PMID: 30303773      PMCID: PMC6347098          DOI: 10.1152/physiol.00029.2018

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN: 1548-9221


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