Literature DB >> 30303619

Methods to Measure MDSC Immune Suppressive Activity In Vitro and In Vivo.

Samantha Solito1, Laura Pinton2, Francesco De Sanctis3, Stefano Ugel3, Vincenzo Bronte3, Susanna Mandruzzato1,2, Ilaria Marigo2.   

Abstract

This unit presents methods to assess the immunosuppressive properties of immunoregulatory cells of myeloid origin, such as myeloid-derived suppressor cells (MDSCs), both in vitro and in vivo in mice, as well as in biological samples from cancer patients. These methods could be adapted to test the impact of different suppressive populations on T cell activation, proliferation, and cytotoxic activity; moreover, they could be useful to assess the influence exerted by genetic modifications, chemical inhibitors, and drugs on immune suppressive pathways
© 2018 by John Wiley & Sons, Inc. © 2018 John Wiley & Sons, Inc.

Entities:  

Keywords:  MDSC; adoptive cell transfer; chromium release test; flow cytometry; immunomagnetic sorting; immunosuppression; thymidine incorporation

Mesh：

Substances：

Year:  2018        PMID： 30303619     DOI： 10.1002/cpim.61

Source DB:  PubMed          Journal:  Curr Protoc Immunol        ISSN： 1934-3671


  12 in total

1.  Single-Cell Transcriptome Analysis Workflow for Splenic Myeloid-Derived Suppressor Cells from Murine Breast Cancer Models.

Authors:  Hamad Alshetaiwi; Nicholas Pervolarakis; Quy H Nguyen; Kai Kessenbrock
Journal:  Methods Mol Biol       Date:  2021

2.  Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3.

Authors:  Rosalinda Trovato; Alessandra Fiore; Sara Sartori; Stefania Canè; Rosalba Giugno; Luciano Cascione; Salvatore Paiella; Roberto Salvia; Francesco De Sanctis; Ornella Poffe; Cristina Anselmi; Francesca Hofer; Silvia Sartoris; Geny Piro; Carmine Carbone; Vincenzo Corbo; Rita Lawlor; Samantha Solito; Laura Pinton; Susanna Mandruzzato; Claudio Bassi; Aldo Scarpa; Vincenzo Bronte; Stefano Ugel
Journal:  J Immunother Cancer       Date:  2019-09-18       Impact factor: 13.751

3.  Deciphering the state of immune silence in fatal COVID-19 patients.

Authors:  Pierre Bost; Francesco De Sanctis; Stefania Canè; Stefano Ugel; Katia Donadello; Monica Castellucci; David Eyal; Alessandra Fiore; Cristina Anselmi; Roza Maria Barouni; Rosalinda Trovato; Simone Caligola; Alessia Lamolinara; Manuela Iezzi; Federica Facciotti; Annarita Mazzariol; Davide Gibellini; Pasquale De Nardo; Evelina Tacconelli; Leonardo Gottin; Enrico Polati; Benno Schwikowski; Ido Amit; Vincenzo Bronte
Journal:  Nat Commun       Date:  2021-03-05       Impact factor: 14.919

4.  CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma.

Authors:  Hadas Lewinsky; Emine G Gunes; Keren David; Lihi Radomir; Matthias P Kramer; Bianca Pellegrino; Michal Perpinial; Jing Chen; Ting-Fang He; Anthony G Mansour; Kun-Yu Teng; Supriyo Bhattacharya; Enrico Caserta; Estelle Troadec; Peter Lee; Mingye Feng; Jonathan Keats; Amrita Krishnan; Michael Rosenzweig; Jianhua Yu; Michael A Caligiuri; Yosef Cohen; Olga Shevetz; Shirly Becker-Herman; Flavia Pichiorri; Steven Rosen; Idit Shachar
Journal:  JCI Insight       Date:  2021-02-22

5.  Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells.

Authors:  Eric Chang-Yi Lin; Shuoh-Wen Chen; Luen-Kui Chen; Ting-An Lin; Yu-Xuan Wu; Chi-Chang Juan; Yuan-I Chang
Journal:  Front Nutr       Date:  2021-11-10

Review 6.  A Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment.

Authors:  Francesca Hofer; Gianna Di Sario; Chiara Musiu; Silvia Sartoris; Francesco De Sanctis; Stefano Ugel
Journal:  Cells       Date:  2021-10-09       Impact factor: 6.600

7.  The immune modulatory effects of umbilical cord-derived mesenchymal stromal cells in severe COVID-19 pneumonia.

Authors:  Rachele Ciccocioppo; Davide Gibellini; Giuseppe Astori; Martina Bernardi; Angela Bozza; Katia Chieregato; Francesca Elice; Stefano Ugel; Simone Caligola; Francesco De Sanctis; Stefania Canè; Alessandra Fiore; Rosalinda Trovato; Antonio Vella; Varvara Petrova; Giuseppe Amodeo; Monica Santimaria; Annarita Mazzariol; Luca Frulloni; Marco Ruggeri; Enrico Polati; Vincenzo Bronte
Journal:  Stem Cell Res Ther       Date:  2021-06-02       Impact factor: 6.832

8.  Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.

Authors:  Mahmoud AbuEid; Donna M McAllister; Laura McOlash; Megan Cleland Harwig; Gang Cheng; Donovan Drouillard; Kathleen A Boyle; Micael Hardy; Jacek Zielonka; Bryon D Johnson; R Blake Hill; Balaraman Kalyanaraman; Michael B Dwinell
Journal:  iScience       Date:  2021-05-25

9.  Physical activity delays accumulation of immunosuppressive myeloid-derived suppressor cells.

Authors:  Jacob Garritson; Luke Krynski; Lea Haverbeck; James M Haughian; Nicholas A Pullen; Reid Hayward
Journal:  PLoS One       Date:  2020-06-15       Impact factor: 3.240

10.  Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.

Authors:  Miguel Reyes; Michael R Filbin; Roby P Bhattacharyya; Abraham Sonny; Arnav Mehta; Kianna Billman; Kyle R Kays; Mayra Pinilla-Vera; Maura E Benson; Lisa A Cosimi; Deborah T Hung; Bruce D Levy; Alexandra-Chloe Villani; Moshe Sade-Feldman; Rebecca M Baron; Marcia B Goldberg; Paul C Blainey; Nir Hacohen
Journal:  Sci Transl Med       Date:  2021-06-08       Impact factor: 17.956
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