Literature DB >> 3030295

Effects of platelet activating factor on the chemotaxis of normodense eosinophils from normal subjects.

N Tamura, D K Agrawal, F A Suliaman, R G Townley.   

Abstract

Highly purified eosinophils were obtained from normal subjects, and their chemotactic responses to platelet activating factor (PAF) were evaluated. PAF induced both eosinophil chemotactic and chemokinetic responses, and was 100 fold more potent eosinophil chemotactic factor as compared to eosinophil chemotactic factor of anaphylaxis. On the other hand, leukotriene B4 did not show any eosinophil chemotactic activity. A selective PAF antagonist, BN52021, inhibited eosinophil chemotaxis in a dose dependent manner. Preincubation of eosinophils with PAF induced the deactivation of eosinophils for further chemotactic responses to PAF. These findings suggest that PAF is a potent chemotactic factor for normal eosinophils.

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Year:  1987        PMID： 3030295     DOI： 10.1016/0006-291x(87)91462-8

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils.

Authors:  H Miyagawa; M Nabe; R J Hopp; C Okada; A K Bewtra; G Townley
Journal:  Agents Actions       Date:  1992-09

Review 2.  The role of eosinophils in asthma.

Authors:  C Kroegel
Journal:  Lung       Date:  1990       Impact factor: 2.584

3.  Characterization of serum platelet-activating factor (PAF) acetylhydrolase. Correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children.

Authors:  M Miwa; T Miyake; T Yamanaka; J Sugatani; Y Suzuki; S Sakata; Y Araki; M Matsumoto
Journal:  J Clin Invest       Date:  1988-12       Impact factor: 14.808

4.  Platelet-activating factor (PAF) and the formation of chronic subdural haematoma. Measurement of plasma PAF levels and anti-PAF immunoglobulin titers.

Authors:  Y Hirashima; S Endo; N Hayashi; K Karasawa; S Nojima; A Takaku
Journal:  Acta Neurochir (Wien)       Date:  1995       Impact factor: 2.216

5.  Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils.

Authors:  P Kernen; M P Wymann; V von Tscharner; D A Deranleau; P C Tai; C J Spry; C A Dahinden; M Baggiolini
Journal:  J Clin Invest       Date:  1991-06       Impact factor: 14.808

6.  Platelet-activating factor (PAF) and the development of chronic subdural haematoma.

Authors:  Y Hirasima; S Endo; R Kato; T Ohmori; T Nagahori; M Nishijima; K Karasawa; S Nojima; A Takaku
Journal:  Acta Neurochir (Wien)       Date:  1994       Impact factor: 2.216

7.  PAF-induced bronchial hyperresponsiveness in the rabbit: contribution of platelets and airway smooth muscle.

Authors:  A J Coyle; D Spina; C P Page
Journal:  Br J Pharmacol       Date:  1990-09       Impact factor: 8.739

8.  Platelet activating factor induced respiratory mucosal damage.

Authors:  K Hisamatsu; T Ganbo; T Nakazawa; Y Murakami
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

9.  The hormonal regulation of platelet-activating factor acetylhydrolase activity in plasma.

Authors:  S Miyaura; N Maki; W Byrd; J M Johnston
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

10.  Platelet-activating factor detected in bronchoalveolar lavage fluids from an asthmatic patient.

Authors:  T Horii; H Okazaki; M Kino; Y Kobayashi; K Satouchi; K Saito
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880
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