Zhaoxia Wang1,2,3, Han Deng1,2,3, Limin Liao4,5,6, Tianji Lu1,2,3, Xing Li1,2,3. 1. Department of Urology, China Rehabilitation Research Centre, Rehabilitation School of Capital Medical University, No 10. Jiaomen Beilu, Fengtai District, Beijing, 100068, China. 2. Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China. 3. Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China. 4. Department of Urology, China Rehabilitation Research Centre, Rehabilitation School of Capital Medical University, No 10. Jiaomen Beilu, Fengtai District, Beijing, 100068, China. lmliao@263.net. 5. Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China. lmliao@263.net. 6. Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China. lmliao@263.net.
Abstract
PURPOSE: To explore the effects of electrical stimulation of the sacral dorsal root ganglion (DRG) on bladder reflexes in α-chloralose-anesthetized cats. METHODS: Bladder activity was recorded under isovolumetric conditions. A pair of hook electrodes was placed in the right S1 and S2 DRGs of 12 adult male cats, which were stimulated over a range of frequencies (0.25-30 Hz) and at threshold intensity. RESULTS: Stimulation of S1 and S2 DRGs inhibited or evoked bladder contractions under isovolumetric conditions depending on the frequency of stimulation in nine cats. Stimulation at low frequencies (3-7 Hz on S1 or S2 DRG) significantly inhibited isovolumetric rhythmic bladder contractions, while excitatory effects were observed at two frequency ranges, including lower frequencies (0.25-1.5 Hz on S1 DRG and 0.25-1.25 Hz on S2 DRG) and middle frequencies (15-30 Hz on S1 and S2 DRGs). CONCLUSIONS: These results suggest that the sacral DRG might be a potential valuable target for electrical stimulation in the treatment of bladder dysfunction.
PURPOSE: To explore the effects of electrical stimulation of the sacral dorsal root ganglion (DRG) on bladder reflexes in α-chloralose-anesthetized cats. METHODS: Bladder activity was recorded under isovolumetric conditions. A pair of hook electrodes was placed in the right S1 and S2 DRGs of 12 adult male cats, which were stimulated over a range of frequencies (0.25-30 Hz) and at threshold intensity. RESULTS: Stimulation of S1 and S2 DRGs inhibited or evoked bladder contractions under isovolumetric conditions depending on the frequency of stimulation in nine cats. Stimulation at low frequencies (3-7 Hz on S1 or S2 DRG) significantly inhibited isovolumetric rhythmic bladder contractions, while excitatory effects were observed at two frequency ranges, including lower frequencies (0.25-1.5 Hz on S1 DRG and 0.25-1.25 Hz on S2 DRG) and middle frequencies (15-30 Hz on S1 and S2 DRGs). CONCLUSIONS: These results suggest that the sacral DRG might be a potential valuable target for electrical stimulation in the treatment of bladder dysfunction.
Authors: Fan Zhang; Shouguo Zhao; Bing Shen; Jicheng Wang; Dwight E Nelson; James R Roppolo; William C de Groat; Changfeng Tai Journal: Am J Physiol Renal Physiol Date: 2013-01-02