Literature DB >> 3030263

Hormonal control of fructose 2,6-bisphosphate concentration in the HT29 human colon adenocarcinoma cell line. Alpha 2-adrenergic agonists counteract effect of vasoactive intestinal peptide.

C Denis, H Paris, J C Murat.   

Abstract

Vasoactive intestinal peptide (VIP) was found to cause a dose-dependent decrease in fructose 2,6-bisphosphatase concomitant with an increase in cyclic AMP in cultured HT29 cancer cells from human colon. The maximum effect was a 41% decrease obtained with 10 nM-VIP, and half-maximum effect was obtained with 0.75 nM-VIP. The effect of 2.5 nM-VIP was almost totally counteracted (i.e. fructose 2,6-bisphosphate concentration was restored) by either adrenaline (1 microM) or the alpha 2-adrenergic agonist UK-14304 (1 microM); the alpha 2-agonist clonidine (1 microM) was less efficient, since the VIP effect was decreased by 72% only. The adrenaline effect was totally antagonized by 1 microM-yohimbine. It is concluded that, in the HT29 cancer cells, the fructose 2,6-bisphosphate-producing system is sensitive to variations of cyclic AMP concentration and is under the dual control of VIP and alpha 2-adrenergic receptors.

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Year:  1986        PMID： 3030263      PMCID： PMC1147319          DOI： 10.1042/bj2390531

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  30 in total

1.  Activation of cyclic AMP-dependent protein kinases in human gut adenocarcinoma (HT 29) cells in culture.

Authors:  J Marvaldi; P Mangeat; O A Ahmed; C Coeroli; G Marchis-Mouren
Journal:  Biochim Biophys Acta       Date:  1979-11-15

2.  Vasoactive intestinal peptide: a potent stimulator of adenosine 3':5'-cyclic monophosphate accumulation in gut carcinoma cell lines in culture.

Authors:  M Laburthe; M Rousset; C Boissard; G Chevalier; A Zweibaum; G Rosselin
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

3.  Radioimmunoassay for cyclic nucleotides. I. Preparation of antibodies and iodinated cyclic nucleotides.

Authors:  A L Steiner; C W Parker; D M Kipnis
Journal:  J Biol Chem       Date:  1972-02-25       Impact factor: 5.157

4.  Evidence for alpha-adrenergic activation and inactivation of phosphorylase in hamster adipocytes.

Authors:  K K McMahon; R J Schimmel
Journal:  Mol Pharmacol       Date:  1981-09       Impact factor: 4.436

Review 5.  One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.

Authors:  J Fogh; J M Fogh; T Orfeo
Journal:  J Natl Cancer Inst       Date:  1977-07       Impact factor: 13.506

6.  Fructose 2,6-bisphosphate. Hormonal regulation and mechanism of its formation in liver.

Authors:  L Hue; P F Blackmore; J H Exton
Journal:  J Biol Chem       Date:  1981-09-10       Impact factor: 5.157

7.  Vasoactive intestinal peptide (VIP) control of glycogenolysis in the human colon carcinoma cell line HT-29 in culture.

Authors:  M Rousset; M Laburthe; G Chevalier; C Boissard; G Rosselin; A Zweibaum
Journal:  FEBS Lett       Date:  1981-04-06       Impact factor: 4.124

8.  Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-bisphosphate.

Authors:  S J Pilkis; M R El-Maghrabi; J Pilkis; T Claus
Journal:  J Biol Chem       Date:  1981-04-25       Impact factor: 5.157

9.  Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase.

Authors:  E Van Schaftingen; L Hue; H G Hers
Journal:  Biochem J       Date:  1980-12-15       Impact factor: 3.857

10.  Fuel utilization in colonocytes of the rat.

Authors:  M S Ardawi; E A Newsholme
Journal:  Biochem J       Date:  1985-11-01       Impact factor: 3.857
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  7 in total

1.  Questions about the use of [3H]thymidine incorporation as a reliable method to estimate cell proliferation rate.

Authors:  J C Murat; L Gamet; Y Cazenave; V Trocheris
Journal:  Biochem J       Date:  1990-09-01       Impact factor: 3.857

Review 2.  Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues.

Authors:  L Hue; M H Rider
Journal:  Biochem J       Date:  1987-07-15       Impact factor: 3.857

3.  Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells.

Authors:  A Remaury; D Larrouy; D Daviaud; B Rouot; H Paris
Journal:  Biochem J       Date:  1993-05-15       Impact factor: 3.857

4.  Insulin controls key steps of carbohydrate metabolism in cultured HT29 colon cancer cells.

Authors:  T Babia; C Denis-Pouxviel; J C Murat; A M Gomez-Foix; V Trocheris; J J Guinovart; F Bosch
Journal:  Biochem J       Date:  1989-07-01       Impact factor: 3.857

5.  Phosphofructokinase 2 and glycolysis in HT29 human colon adenocarcinoma cell line. Regulation by insulin and phorbol esters.

Authors:  C Denis-Pouxviel; T Gauthier; D Daviaud; J C Murat
Journal:  Biochem J       Date:  1990-06-01       Impact factor: 3.857

6.  An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect.

Authors:  J Chesney; R Mitchell; F Benigni; M Bacher; L Spiegel; Y Al-Abed; J H Han; C Metz; R Bucala
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-16       Impact factor: 11.205

7.  Fructose 2,6-bisphosphate metabolism in Ehrlich ascites tumour cells.

Authors:  K Nissler; H Petermann; I Wenz; D Brox
Journal:  J Cancer Res Clin Oncol       Date:  1995       Impact factor: 4.553
  7 in total

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