AIM: We aimed to understand the biology of chronic lymphocytic leukemia (CLL) patients in Lebanon. MATERIALS & METHODS: We applied conventional cytogenetic and FISH studies on Lebanese patients diagnosed with CLL and undergoing a watch and wait approach. RESULTS: Our study disclosed 53.6% of patients with aberrant karyotypes among which 26.7% were complex karyotypes. Genetic aberrations included del(13q14) 46.4%, 14q32 translocation in 25%, trisomy 12 in 14.3%, del(17p13) and del(11q22) in 7.1% each. The deletion of 6q21/6q23 was not found in any of our patients. CONCLUSION: The higher prevalence of del(13q14) as a sole abnormality could be the primary event in inducing CLL. The del(17p13) and del(11q22) followed as potential drivers for progression in CLL patients with a watch and wait approach.
AIM: We aimed to understand the biology of chronic lymphocytic leukemia (CLL) patients in Lebanon. MATERIALS & METHODS: We applied conventional cytogenetic and FISH studies on Lebanese patients diagnosed with CLL and undergoing a watch and wait approach. RESULTS: Our study disclosed 53.6% of patients with aberrant karyotypes among which 26.7% were complex karyotypes. Genetic aberrations included del(13q14) 46.4%, 14q32 translocation in 25%, trisomy 12 in 14.3%, del(17p13) and del(11q22) in 7.1% each. The deletion of 6q21/6q23 was not found in any of our patients. CONCLUSION: The higher prevalence of del(13q14) as a sole abnormality could be the primary event in inducing CLL. The del(17p13) and del(11q22) followed as potential drivers for progression in CLL patients with a watch and wait approach.
Entities:
Keywords:
Middle East; chronic lymphocytic leukemia; fluorescence in situ hybridization; molecular characteristics; small lymphocytic lymphoma
Authors: P S Kadam Amare; V Gadage; H Jain; S Nikalje; S Manju; N Mittal; S Gujral; R Nair Journal: Indian J Cancer Date: 2013 Jul-Sep Impact factor: 1.224
Authors: J L Binet; M Leporrier; G Dighiero; D Charron; P D'Athis; G Vaugier; H M Beral; J C Natali; M Raphael; B Nizet; J Y Follezou Journal: Cancer Date: 1977-08 Impact factor: 6.860
Authors: Anna Puiggros; Rosa Collado; Maria José Calasanz; Margarita Ortega; Neus Ruiz-Xivillé; Alfredo Rivas-Delgado; Elisa Luño; Teresa González; Blanca Navarro; MaDolores García-Malo; Alberto Valiente; José Ángel Hernández; María Teresa Ardanaz; María Ángeles Piñan; María Laura Blanco; María Hernández-Sánchez; Ana Batlle-López; Rocío Salgado; Marta Salido; Ana Ferrer; Pau Abrisqueta; Eva Gimeno; Eugènia Abella; Christelle Ferrá; María José Terol; Francisco Ortuño; Dolors Costa; Carol Moreno; Félix Carbonell; Francesc Bosch; Julio Delgado; Blanca Espinet Journal: Oncotarget Date: 2017-04-21