Taweesak Tongtawee1, Theeraya Simawaranon1, Wareeporn Wattanawongdon1, Chavaboon Dechsukhum2, Wilairat Leeanansaksiri3. 1. Department of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand. 2. School of Pathology, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand. 3. School of Preclinic, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
Abstract
BACKGROUND/AIMS: Genetic polymorphisms in Toll-like receptors (TLRs) are important influence on gastric lesion development and Helicobacter pylori susceptibility. MATERIALS AND METHODS: TLR2 rs3804099 and rs3804100 and TLR4 rs10759932 were determined in a total of 400 patients. The association among genotypes and the risk of gastric lesion development and H. pylori susceptibility were evaluated by the odds ratios (ORs) and 95% confidence intervals (95% CIs) from logistic regression analyses. RESULTS: TLR4 rs10759932, C/C homozygous genotype was associated with an increased risk of premalignant/malignant (OR=2.48, 95% CI=1.96-4.62, p=0.015). The recessive model of TLR4 rs10759932 showed a decreased risk of H. pylori susceptibility (adjusted OR=0.52, 95% CI=0.38-0.82, p=0.046). Meanwhile, the recessive model was associated with an increased risk of non-malignant (OR=3.46, 95% CI=2.25-5.67, p=0.001). In subjects with H. pylori infection, the recessive model was associated with an increased risk of non-malignant (OR=2.28, 95% CI=1.24-3.57, p=0.001) and premalignant/malignant (OR=1.83, 95% CI=1.16-2.84, p=0.027). CONCLUSION: TLR4 rs10759932, but not TLR2 rs3804099 and rs3804100, was associated with risk of premalignant and/or malignant and H. pylori susceptibility. H. pylori infection seems to contribute to chronic gastritis, and premalignant/malignant supported the development of the premalignant/malignant lesions involved in H. pylori infection that is critical to gastric cancer in Thai patients.
BACKGROUND/AIMS: Genetic polymorphisms in Toll-like receptors (TLRs) are important influence on gastric lesion development and Helicobacter pylori susceptibility. MATERIALS AND METHODS:TLR2rs3804099 and rs3804100 and TLR4rs10759932 were determined in a total of 400 patients. The association among genotypes and the risk of gastric lesion development and H. pylori susceptibility were evaluated by the odds ratios (ORs) and 95% confidence intervals (95% CIs) from logistic regression analyses. RESULTS:TLR4rs10759932, C/C homozygous genotype was associated with an increased risk of premalignant/malignant (OR=2.48, 95% CI=1.96-4.62, p=0.015). The recessive model of TLR4rs10759932 showed a decreased risk of H. pylori susceptibility (adjusted OR=0.52, 95% CI=0.38-0.82, p=0.046). Meanwhile, the recessive model was associated with an increased risk of non-malignant (OR=3.46, 95% CI=2.25-5.67, p=0.001). In subjects with H. pyloriinfection, the recessive model was associated with an increased risk of non-malignant (OR=2.28, 95% CI=1.24-3.57, p=0.001) and premalignant/malignant (OR=1.83, 95% CI=1.16-2.84, p=0.027). CONCLUSION:TLR4rs10759932, but not TLR2rs3804099 and rs3804100, was associated with risk of premalignant and/or malignant and H. pylori susceptibility. H. pyloriinfection seems to contribute to chronic gastritis, and premalignant/malignant supported the development of the premalignant/malignant lesions involved in H. pyloriinfection that is critical to gastric cancer in Thai patients.
Authors: Yi Ying Cheok; Grace Min Yi Tan; Chalystha Yie Qin Lee; Suhailah Abdullah; Chung Yeng Looi; Won Fen Wong Journal: Int J Mol Sci Date: 2022-07-08 Impact factor: 6.208
Authors: Caroline de Matos Lourenço; Manoela Dias Susi; Mariah Cristina Antunes do Nascimento; Vilson Serafim Junior; Ana Paula Simedan Vila; Gabriela Helena Rodrigues-Flemming; Eny Maria Goloni-Bertollo; Ana Elizabete Silva; Juliana Garcia de Oliveira-Cucolo Journal: World J Gastrointest Oncol Date: 2020-05-15