| Literature DB >> 30300578 |
Jiao Yuan1, Zhongyi Hu1, Brandon A Mahal2, Sihai D Zhao3, Kevin H Kensler4, Jingjiang Pi5, Xiaowen Hu1, Youyou Zhang1, Yueying Wang1, Junjie Jiang1, Chunsheng Li1, Xiaomin Zhong6, Kathleen T Montone7, Guoqiang Guan8, Janos L Tanyi9, Yi Fan10, Xiaowei Xu7, Mark A Morgan9, Meixiao Long11, Yuzhen Zhang5, Rugang Zhang12, Anil K Sood13, Timothy R Rebbeck4, Chi V Dang14, Lin Zhang15.
Abstract
Disparities in cancer care have been a long-standing challenge. We estimated the genetic ancestry of The Cancer Genome Atlas patients, and performed a pan-cancer analysis on the influence of genetic ancestry on genomic alterations. Compared with European Americans, African Americans (AA) with breast, head and neck, and endometrial cancers exhibit a higher level of chromosomal instability, while a lower level of chromosomal instability was observed in AAs with kidney cancers. The frequencies of TP53 mutations and amplification of CCNE1 were increased in AAs in the cancer types showing higher levels of chromosomal instability. We observed lower frequencies of genomic alterations affecting genes in the PI3K pathway in AA patients across cancers. Our result provides insight into genomic contribution to cancer disparities.Entities:
Keywords: cancer disparities; cancer genetics; cancer genomics
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Year: 2018 PMID： 30300578 PMCID： PMC6348897 DOI： 10.1016/j.ccell.2018.08.019
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743