Literature DB >> 30299504

Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.

Anatoliy I Yashin1, Konstantin G Arbeev1, Deqing Wu1, Liubov S Arbeeva2, Olivia Bagley1, Eric Stallard1, Alexander M Kulminski1, Igor Akushevich1, Fang Fang1, Mary K Wojczynski3, Kaare Christensen4, Anne B Newman5, Robert M Boudreau5, Michael A Province6, Stephen Thielke7, Thomas T Perls8, Ping An3, Irma Elo9, Svetlana V Ukraintseva1.   

Abstract

The special design of the Long Life Family Study provides a unique opportunity to investigate the genetics of human longevity by analyzing data on exceptional lifespans in families. In this article, we performed two series of genome wide association studies of human longevity which differed with respect to whether missing lifespan data were predicted or not predicted. We showed that the use of predicted lifespan is most beneficial when the follow-up period is relatively short. In addition to detection of strong associations of SNPs in APOE, TOMM40, NECTIN2, and APOC1 genes with longevity, we also detected a strong new association with longevity of rs1927465, located between the CYP26A1 and MYOF genes on chromosome 10. The association was confirmed using data from the Health and Retirement Study. We discuss the biological relevance of the detected SNPs to human longevity.

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Year:  2018        PMID： 30299504      PMCID： PMC6175028          DOI： 10.1093/gerona/gly057

Source DB:  PubMed          Journal:  J Gerontol A Biol Sci Med Sci        ISSN： 1079-5006            Impact factor:   6.053


  52 in total

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