Literature DB >> 30297363

Polymorphism of Polymeric Amino Acid Regions in Fungal Proteins and Correlation with Altered Echinocandin and Azole Susceptibility.

Krishna Challa1, Tom Edlind2, Santosh Katiyar3.   

Abstract

Polymorphism of polymeric amino acid (polyX) regions within fungal proteins represents a potential mechanism for rapid genotypic adaptation to environmental pressures, including antifungal exposure. Polyglutamine (polyQ) was the most abundant repeat in the proteomes of 8 diverse fungal species and was preferentially found in regulatory proteins. In Candida glabrata, polyX polymorphisms were characterized in 36 proteins implicated in azole or echinocandin susceptibility. General transcriptional repressor Tup1A exhibited Q44/Q45 polymorphism, and Hog1 signaling component Ssk2 exhibited N44/N45 polymorphism in phylogenetically matched echinocandin- and azole-susceptible/resistant strains, respectively.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  Candida glabratazzm321990; polymorphism

Mesh：

Substances：

Year:  2018        PMID： 30297363      PMCID： PMC6256777          DOI： 10.1128/AAC.00870-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Polyglutamine tracts as modulators of transcriptional activation from yeast to mammals.

Authors:  Lilit Atanesyan; Viola Günther; Bernhard Dichtl; Oleg Georgiev; Walter Schaffner
Journal:  Biol Chem       Date:  2012-01       Impact factor: 3.915

Review 2.  Variable tandem repeats accelerate evolution of coding and regulatory sequences.

Authors:  Rita Gemayel; Marcelo D Vinces; Matthieu Legendre; Kevin J Verstrepen
Journal:  Annu Rev Genet       Date:  2010       Impact factor: 16.830

Review 3.  The role of variable DNA tandem repeats in bacterial adaptation.

Authors:  Kai Zhou; Abram Aertsen; Chris W Michiels
Journal:  FEMS Microbiol Rev       Date:  2013-08-28       Impact factor: 16.408

4.  New microsatellite multiplex PCR for Candida albicans strain typing reveals microevolutionary changes.

Authors:  Paula Sampaio; Leonor Gusmão; Alexandra Correia; Cíntia Alves; Acácio G Rodrigues; Cidália Pina-Vaz; António Amorim; Célia Pais
Journal:  J Clin Microbiol       Date:  2005-08       Impact factor: 5.948

5.  Candida glabrata mutants demonstrating paradoxical reduced caspofungin susceptibility but increased micafungin susceptibility.

Authors:  Kelley R Healey; Santosh K Katiyar; Mariana Castanheira; Michael A Pfaller; Thomas D Edlind
Journal:  Antimicrob Agents Chemother       Date:  2011-05-31       Impact factor: 5.191

6.  Regulation of the CgPdr1 transcription factor from the pathogen Candida glabrata.

Authors:  Sanjoy Paul; Jennifer A Schmidt; W Scott Moye-Rowley
Journal:  Eukaryot Cell       Date:  2010-12-03

7.  Increased number of glutamine repeats in the C-terminal of Candida albicans Rlm1p enhances the resistance to stress agents.

Authors:  Paula Sampaio; Eugénia Nogueira; Ana Sá Loureiro; Yolanda Delgado-Silva; Alexandra Correia; Célia Pais
Journal:  Antonie Van Leeuwenhoek       Date:  2009-05-31       Impact factor: 2.271

8.  The high-osmolarity glycerol response pathway in the human fungal pathogen Candida glabrata strain ATCC 2001 lacks a signaling branch that operates in baker's yeast.

Authors:  Christa Gregori; Christoph Schüller; Andreas Roetzer; Tobias Schwarzmüller; Gustav Ammerer; Karl Kuchler
Journal:  Eukaryot Cell       Date:  2007-07-06

9.  Pivotal role for a tail subunit of the RNA polymerase II mediator complex CgMed2 in azole tolerance and adherence in Candida glabrata.

Authors:  Sapan Borah; Raju Shivarathri; Vivek Kumar Srivastava; Sélène Ferrari; Dominique Sanglard; Rupinder Kaur
Journal:  Antimicrob Agents Chemother       Date:  2014-07-28       Impact factor: 5.191

10.  Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes.

Authors:  Tobias Schwarzmüller; Biao Ma; Ekkehard Hiller; Fabian Istel; Michael Tscherner; Sascha Brunke; Lauren Ames; Arnaud Firon; Brian Green; Vitor Cabral; Marina Marcet-Houben; Ilse D Jacobsen; Jessica Quintin; Katja Seider; Ingrid Frohner; Walter Glaser; Helmut Jungwirth; Sophie Bachellier-Bassi; Murielle Chauvel; Ute Zeidler; Dominique Ferrandon; Toni Gabaldón; Bernhard Hube; Christophe d'Enfert; Steffen Rupp; Brendan Cormack; Ken Haynes; Karl Kuchler
Journal:  PLoS Pathog       Date:  2014-06-19       Impact factor: 6.823
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