| Literature DB >> 30296550 |
Jianguo Cui1, Liping Pang2, Meizhen Wei2, Chunfang Gan2, Dandan Liu2, Haiyan Yuan2, Yanmin Huang3.
Abstract
Using pregnenolone as a starting material, some 3-substituted 17-[1',2',3']-selenadiazolylpregnenolone derivatives were synthesized, and their structures were characterized by IR, NMR and HRMS. The in vitro antitumor activity of the compounds was assayed against PC-3、SKOV3、T47D、MCF-7 and HEK293T cell lines. The results show that some compounds display selective antiproliferative activity against PC-3 and SKOV3 cells lines and are almost inactive to normal kidney epithelial cells (HEK293T). The IC50 value are much better than that of abiraterone (positive control).Entities:
Keywords: 17-[1′,2′,3′]-Selenadiazolylpregnenolone; Antiproliferative activity; Organoselenium compounds; Pregnenolone; [1′,2′,3′]-Selenadiazole
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Year: 2018 PMID： 30296550 DOI： 10.1016/j.steroids.2018.10.004
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668