Petra Bogovič1, Stanka Lotrič-Furlan2, Tatjana Avšič-Županc3, Lara Lusa4, Franc Strle5. 1. Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Electronic address: petra.bogovic@kclj.si. 2. Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia. 3. Institute for Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. 4. Institute for Biostatistics and Medical Informatics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia; Department of Mathematics, Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Koper, Slovenia. 5. Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Abstract
BACKGROUND: Information on parameters associated with the severity of tick-borne encephalitis (TBE) is limited. METHODS: The association between 15 pre-defined parameters and the severity of TBE was evaluated in 717 consecutive adult patients diagnosed in Slovenia 2007-2012. RESULTS: Multivariable logistic regression showed that patient age (odds ratio, OR 1.26, 95% CI 1.11-1.44; P = 0.001), previous vaccination against TBE (OR 14.23, 95% CI 1.72-117.87; P = 0.014), blood leukocyte count (OR 1.45, 95% CI 1.13-1.85; P = 0.004), and level of specific TBE virus serum IgG antibodies (OR 0.85, 95% CI 0.75-0.96; P = 0.009) were associated with severe acute illness based on the clinical diagnosis. When severity of TBE was based on the severity score and linear regression was used, corresponding association was found for age (estimated coefficient, EC 1.70, 95% CI 1.06-2.33; P<0.001), previous vaccination against TBE (EC 11.16, 95% CI 5.05-17.27; P < 0.001), serum C-reactive protein level (EC 1.20, 95% CI 0.48-1.91; P = 0.001), and level of specific TBE virus serum IgG antibodies (EC -0.74, 95% CI -1.27-0.20; P = 0.007). CONCLUSIONS: Previous vaccination against TBE, low levels of TBE virus serum IgG antibodies, older age, higher blood leukocyte count, and higher serum C-reactive protein levels are associated with more severe TBE.
BACKGROUND: Information on parameters associated with the severity of tick-borne encephalitis (TBE) is limited. METHODS: The association between 15 pre-defined parameters and the severity of TBE was evaluated in 717 consecutive adult patients diagnosed in Slovenia 2007-2012. RESULTS: Multivariable logistic regression showed that patient age (odds ratio, OR 1.26, 95% CI 1.11-1.44; P = 0.001), previous vaccination against TBE (OR 14.23, 95% CI 1.72-117.87; P = 0.014), blood leukocyte count (OR 1.45, 95% CI 1.13-1.85; P = 0.004), and level of specific TBE virus serum IgG antibodies (OR 0.85, 95% CI 0.75-0.96; P = 0.009) were associated with severe acute illness based on the clinical diagnosis. When severity of TBE was based on the severity score and linear regression was used, corresponding association was found for age (estimated coefficient, EC 1.70, 95% CI 1.06-2.33; P<0.001), previous vaccination against TBE (EC 11.16, 95% CI 5.05-17.27; P < 0.001), serum C-reactive protein level (EC 1.20, 95% CI 0.48-1.91; P = 0.001), and level of specific TBE virus serum IgG antibodies (EC -0.74, 95% CI -1.27-0.20; P = 0.007). CONCLUSIONS: Previous vaccination against TBE, low levels of TBE virus serum IgG antibodies, older age, higher blood leukocyte count, and higher serum C-reactive protein levels are associated with more severe TBE.
Authors: Samo Zakotnik; Nataša Knap; Petra Bogovič; Tomaž Mark Zorec; Mario Poljak; Franc Strle; Tatjana Avšič-Županc; Miša Korva Journal: Viruses Date: 2022-06-10 Impact factor: 5.818
Authors: Benno Kohlmaier; Nina A Schweintzger; Manfred G Sagmeister; Vendula Švendová; Daniela S Kohlfürst; Astrid Sonnleitner; Manuel Leitner; Andrea Berghold; Erich Schmiedberger; Franz Fazekas; Alexander Pichler; Jana Rejc-Marko; Daniel Růžek; Lucie Dufková; Darina Čejková; Petr Husa; Martina Pýchová; Lenka Krbková; Václav Chmelík; Věra Štruncová; Dace Zavadska; Guntis Karelis; Aukse Mickiene; Joanna Zajkowska; Petra Bogovič; Franc Strle; Werner Zenz Journal: Microorganisms Date: 2021-06-30