Lori-Ann R Sacrey1,2, Lonnie Zwaigenbaum1,2, Susan Bryson3, Jessica Brian4,5, Isabel M Smith3, Sarah Raza1,2, Wendy Roberts6, Peter Szatmari5,7,8, Tracy Vaillancourt9, Caroline Roncadin5,10, Nancy Garon11. 1. Department of Pediatrics, University of Alberta, Edmonton, AB, Canada. 2. Autism Research Centre, Glenrose Rehabilitation Hospital, Edmonton, AB, Canada. 3. Dalhousie University/IWK Health Centre, Halifax, NS, Canada. 4. Bloorview Research Institute, Toronto, ON, Canada. 5. University of Toronto, Toronto, ON, Canada. 6. ISAND, Toronto, ON, Canada. 7. The Hospital for Sick Children, Toronto, ON, Canada. 8. Centre for Addiction and Mental Health, Toronto, ON, Canada. 9. University of Ottawa, Ottawa, ON, Canada. 10. McMaster Children's Hospital/Hamilton Health Sciences, Hamilton, ON, Canada. 11. Mount Allison University, Sackville, NB, Canada.
Abstract
BACKGROUND: Children with autism spectrum disorder (ASD) often experience impairments in adaptive behavior. METHODS: Developmental trajectories of adaptive behavior in ASD were examined in children from high-risk (siblings of children diagnosed with ASD, n = 403) and low-risk (no family history of ASD, n = 163) families. Children were assessed prospectively at 12, 18, 24, and 36 months of age using the Vineland Adaptive Behavior Scales and underwent a blind independent diagnostic assessment for ASD at 36 months of age. RESULTS: The semi-parametric group-based modeling approach using standard scores on the Adaptive Behavior Composite revealed three distinct developmental trajectories: (a) Group 1 (21.2% of sample) showed average performance at 12 months and a declining trajectory; (b) Group 2 (52.8% of the sample) showed average performance at 12 months with a slightly declining trajectory; and (c) Group 3 (26.0% of the sample) showed a higher level of adaptive behavior at 12 months and a stable trajectory. The Mullen Scales of Early Learning Early Learning Composite and the Autism Observation Scale for Infants total score at 6 and 12 months predicted trajectory membership. CONCLUSIONS: The results emphasize heterogeneous development associated with ASD and the need for interventions tailored to individual presentations.
BACKGROUND:Children with autism spectrum disorder (ASD) often experience impairments in adaptive behavior. METHODS: Developmental trajectories of adaptive behavior in ASD were examined in children from high-risk (siblings of children diagnosed with ASD, n = 403) and low-risk (no family history of ASD, n = 163) families. Children were assessed prospectively at 12, 18, 24, and 36 months of age using the Vineland Adaptive Behavior Scales and underwent a blind independent diagnostic assessment for ASD at 36 months of age. RESULTS: The semi-parametric group-based modeling approach using standard scores on the Adaptive Behavior Composite revealed three distinct developmental trajectories: (a) Group 1 (21.2% of sample) showed average performance at 12 months and a declining trajectory; (b) Group 2 (52.8% of the sample) showed average performance at 12 months with a slightly declining trajectory; and (c) Group 3 (26.0% of the sample) showed a higher level of adaptive behavior at 12 months and a stable trajectory. The Mullen Scales of Early Learning Early Learning Composite and the Autism Observation Scale for Infants total score at 6 and 12 months predicted trajectory membership. CONCLUSIONS: The results emphasize heterogeneous development associated with ASD and the need for interventions tailored to individual presentations.
Authors: Alexandra Hendry; Emily J H Jones; Rachael Bedford; Linn Andersson Konke; Jannath Begum Ali; Sven Bӧlte; Karin C Brocki; Ellen Demurie; Mark Johnson; Mirjam K J Pijl; Herbert Roeyers; Tony Charman Journal: J Autism Dev Disord Date: 2020-11
Authors: Joseph Piven; Jason Wolff; Pang Chaxiong; Catherine Burrows; Kelly N Botteron; Stephen R Dager; Annette M Estes; Heather C Hazlett; Robert T Schultz; Lonnie Zwaigenbaum Journal: J Autism Dev Disord Date: 2021-05-06