Literature DB >> 3029484

Effect of calcitonin gene-related peptide on the cyclic AMP level of isolated mouse diaphragm.

K Takami, K Hashimoto, S Uchida, M Tohyama, H Yoshida.   

Abstract

The effect of calcitonin gene-related peptide (CGRP) on the cyclic nucleotide level in isolated mouse diaphragm was investigated. CGRP at concentrations of up to 1 microM caused dose-dependent increases in cyclic AMP levels but had no effect on cyclic GMP levels. At 1 microM, CGRP increased cyclic AMP levels by about 2.7-fold. Moreover, in the presence of phosphodiesterase inhibitor (Ro 20-1724), CGRP still caused even greater dose-dependent increases in cyclic AMP levels. Even in the presence of propranolol, a beta-adrenergic antagonist, CGRP stimulated increased cyclic AMP levels. In addition, specific binding of CGRP was observed in mouse diaphragm. All these results suggest that CGRP increases intracellular cyclic AMP levels via a CGRP receptor but not the beta-adrenergic receptor.

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Year:  1986        PMID： 3029484     DOI： 10.1254/jjp.42.345

Source DB:  PubMed          Journal:  Jpn J Pharmacol        ISSN： 0021-5198


  17 in total

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Review 3.  Regulation of nicotinic acetylcholine receptors by protein phosphorylation.

Authors:  K Miles; R L Huganir
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Review 4.  Peptides from the calcitonin genes: molecular genetics, structure and function.

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Journal:  Biochem J       Date:  1988-10-15       Impact factor: 3.857

Review 5.  Activity-dependent regulation of gene expression in muscle and neuronal cells.

Authors:  R Laufer; J P Changeux
Journal:  Mol Neurobiol       Date:  1989 Spring-Summer       Impact factor: 5.590

6.  A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system.

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7.  Characterization of P2-purinoceptor mediated cyclic AMP formation in mouse C2C12 myotubes.

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8.  Increased calcitonin gene-related peptide- and cholecystokinin-like immunoreactivities in spinal motoneurones after dorsal rhizotomy.

Authors:  H Taquet; J J Plachot; M Pohl; E Collin; J J Benoliel; S Bourgoin; A Mauborgne; J C Meunier; F Cesselin; M Hamon
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9.  Sustained CGRP1 receptor stimulation modulates development of EC coupling by cAMP/PKA signalling pathway in mouse skeletal myotubes.

Authors:  Guillermo Avila; Citlalli I Aguilar; Roberto Ramos-Mondragón
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10.  Calcitonin gene related peptide stimulates adenylate cyclase activity in rat striated muscle.

Authors:  H Kobayashi; K Hashimoto; S Uchida; J Sakuma; K Takami; M Tohyama; F Izumi; H Yoshida
Journal:  Experientia       Date:  1987-03-15
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