| Literature DB >> 3029448 |
C Kishimoto, C J Spry, P C Tai, N Tomioka, C Kawai.
Abstract
We studied the in vivo effects of eosinophilic cationic protein (ECP) on DBA/2 mice, and compared the cardiac lesions caused by ECP with those caused by encephalomyocarditis (EMC) virus. ECP caused myocarditis in two of five mice (40%), and EMC virus did so in five of five mice (100%). Cardiac lesions of ECP were mild and limited to the right ventricular wall, which differed from those in the mice with EMC virus inoculation, where both the right and left ventricles were involved. This experiment is the first demonstration of the in vivo cardiotoxicity of ECP.Entities:
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Year: 1986 PMID： 3029448 DOI： 10.1253/jcj.50.1264
Source DB: PubMed Journal: Jpn Circ J ISSN： 0047-1828