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Literature DB >> 3029427

Isolation and characterization of phosphonoacetic acid-resistant mutants of human cytomegalovirus.

Abstract

Mutants of the human cytomegalovirus (HCMV) that were 6- to 13-fold more resistant to phosphonoacetic acid than the wild-type HCMV (Towne) were isolated. Extracts from mycoplasma-free, mutant-infected cells had phosphonoacetate-resistant DNA polymerase activity in vitro. This strongly suggests that the selected mutations are in the HCMV DNA polymerase genes of these viruses.

Entities: Chemical Disease Species

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Year: 1987 PMID： 3029427 PMCID： PMC254097 DOI： 10.1128/JVI.61.4.1291-1295.1987

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

52 in total

1. Morphogenesis of nuclear inclusions and virus capsids in HEL cells infected with temperature-sensitive mutants of human cytomegalovirus.

Authors: F Maeda; S Ihara; Y Watanabe
Journal: J Gen Virol Date: 1979-08 Impact factor: 3.891

2. Cytomegalovirus-infected cells contain a DNA-binding protein.

Authors: W Gibson; T L Murphy; C Roby
Journal: Virology Date: 1981-05 Impact factor: 3.616

3. Human cytomegalovirus DNA: restriction enzyme cleavage maps and map locations for immediate-early, early, and late RNAs.

Authors: J M Demarchi
Journal: Virology Date: 1981-10-15 Impact factor: 3.616

4. Physical mapping of paar mutations of herpes simplex virus type 1 and type 2 by intertypic marker rescue.

Authors: P Chartrand; N D Stow; M C Timbury; N M Wilkie
Journal: J Virol Date: 1979-08 Impact factor: 5.103

5. Characterization of the DNA polymerases induced by a group of herpes simplex virus type I variants selected for growth in the presence of phosphonoformic acid.

Authors: D Derse; K F Bastow; Y Cheng
Journal: J Biol Chem Date: 1982-09-10 Impact factor: 5.157

6. Resistance of herpes simplex virus to adenine arabinoside and E-5-(2-bromovinyl)-2'-deoxyuridine: a physical analysis.

Authors: C S Crumpacker; L E Schnipper; P N Kowalsky; D M Sherman
Journal: J Infect Dis Date: 1982-08 Impact factor: 5.226

7. Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine.

Authors: D M Coen; P A Furman; P T Gelep; P A Schaffer
Journal: J Virol Date: 1982-03 Impact factor: 5.103

8. Characterization of human cytomegalovirus-induced DNA polymerase and the associated 3'-to-5', exonuclease.

Authors: Y Nishiyama; K Maeno; S Yoshida
Journal: Virology Date: 1983-01-30 Impact factor: 3.616

9. Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.

Authors: P A Furman; D M Coen; M H St Clair; P A Schaffer
Journal: J Virol Date: 1981-12 Impact factor: 5.103

10. Physical mapping of drug resistance mutations defines an active center of the herpes simplex virus DNA polymerase enzyme.

Authors: K W Knopf; E R Kaufman; C Crumpacker
Journal: J Virol Date: 1981-09 Impact factor: 5.103

7 in total

Review 1. Recent advances in cloning herpesviral genomes as infectious bacterial artificial chromosomes.

Authors: Fuchun Zhou; Shou-Jiang Gao
Journal: Cell Cycle Date: 2011-02-01 Impact factor: 4.534

2. Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS.

Authors: F Baldanti; M R Underwood; S C Stanat; K K Biron; S Chou; A Sarasini; E Silini; G Gerna
Journal: J Virol Date: 1996-03 Impact factor: 5.103