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Literature DB >> 30293943

Resistance to molecularly targeted therapy in non-small-cell lung cancer.

Tetsuhiko Asao¹, Fumiyuki Takahashi², Kazuhisa Takahashi².

Abstract

The discovery of oncogenic driver gene mutations, including epidermal growth factor receptor (EGFR) mutation, anaplastic lymphoma kinase (ALK) fusion, ROS proto-oncogene 1 (ROS1) fusion, and ret proto-oncogene (RET) fusion, has led to the development of molecularly targeted therapy for non-small-cell lung cancer (NSCLC). This therapy has changed the standard of care for NSCLC. Despite the dramatic response to molecularly targeted therapy, almost all patients ultimately develop resistance to the drugs. To understand the mechanisms of resistance to molecularly targeted agents, it is essential to understand the molecular pathways of NSCLC. Here, we review the mechanisms of resistance to molecularly targeted therapy and discuss strategies to overcome drug resistance.

Entities: Disease Gene Species

Keywords: ALK; Acquired resistance; EGFR; Lung cancer; Molecularly targeted therapy

Mesh：

Substances：

Year: 2018 PMID： 30293943 DOI： 10.1016/j.resinv.2018.09.001

Source DB: PubMed Journal: Respir Investig ISSN： 2212-5345

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Cited

17 in total

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4. Repression of Hexokinases II-Mediated Glycolysis Contributes to Piperlongumine-Induced Tumor Suppression in Non-Small Cell Lung Cancer Cells.

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5. TKI-resistant ALK-rearranged lung adenocarcinoma with secondary CTNNB1 p.S45V and tertiary ALK p.I1171N mutations.

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Review 6. Translating Systems Medicine Into Clinical Practice: Examples From Pulmonary Medicine With Genetic Disorders, Infections, Inflammations, Cancer Genesis, and Treatment Implication of Molecular Alterations in Non-small-cell Lung Cancers and Personalized Medicine.

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Resistance to molecularly targeted therapy in non-small-cell lung cancer.

1. Synergistic inhibitory effect of berberine and icotinib on non-small cell lung cancer cells via inducing autophagic cell death and apoptosis.

2. Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models.

Review 3. Anticancer peptide: Physicochemical property, functional aspect and trend in clinical application (Review).

4. Repression of Hexokinases II-Mediated Glycolysis Contributes to Piperlongumine-Induced Tumor Suppression in Non-Small Cell Lung Cancer Cells.

5. TKI-resistant ALK-rearranged lung adenocarcinoma with secondary CTNNB1 p.S45V and tertiary ALK p.I1171N mutations.

Review 6. Translating Systems Medicine Into Clinical Practice: Examples From Pulmonary Medicine With Genetic Disorders, Infections, Inflammations, Cancer Genesis, and Treatment Implication of Molecular Alterations in Non-small-cell Lung Cancers and Personalized Medicine.

7. Transformation of Two Cases of Lung Adenocarcinoma into Pulmonary Sarcomatoid Carcinoma following Treatment.

Review 8. Recent Advances and Future Perspective of DC-Based Therapy in NSCLC.

Review 9. Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells.

10. Pulmonary pleomorphic carcinoma with pembrolizumab monotherapy.