Literature DB >> 3029307

Human epithelial cell expression of an Epstein-Barr virus receptor.

J W Sixbey, D S Davis, L S Young, L Hutt-Fletcher, T F Tedder, A B Rickinson.   

Abstract

Cultured human epithelium bound and internalized radiolabelled Epstein-Barr virus (EBV) within 1 h of exposure. A similar percentage of cultured cells also were reactive with monoclonal antibodies to the EBV/C3d receptor of B lymphocytes. In cross-sections of fresh frozen, stratified epithelium, receptor expression seemed limited to the less differentiated subpopulation of cells. These findings support the notion of direct infection of epithelial cells by EBV and suggest a viral life cycle in epithelium dependent on the stage of cell differentiation.

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Year:  1987        PMID： 3029307     DOI： 10.1099/0022-1317-68-3-805

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  39 in total

1.  The mechanism of Epstein-Barr virus infection in nasopharyngeal carcinoma cells.

Authors:  C T Lin; C R Lin; G K Tan; W Chen; A N Dee; W Y Chan
Journal:  Am J Pathol       Date:  1997-05       Impact factor: 4.307

2.  Modulation of the growth and morphology of a human nasopharyngeal carcinoma cell line by growth factors.

Authors:  J K Chen; Y S Chang; S S Lin; H H Chao
Journal:  In Vitro Cell Dev Biol       Date:  1992 Sep-Oct

3.  Epstein-Barr virus enters B cells and epithelial cells by different routes.

Authors:  N Miller; L M Hutt-Fletcher
Journal:  J Virol       Date:  1992-06       Impact factor: 5.103

Review 4.  Epstein-Barr virus tissue tropism: a major determinant of immunopathogenesis.

Authors:  L Hutt-Fletcher
Journal:  Springer Semin Immunopathol       Date:  1991

Review 5.  Molecular basis for Epstein-Barr virus induced pathogenesis and disease.

Authors:  C Sample; E Kieff
Journal:  Springer Semin Immunopathol       Date:  1991

6.  Expression of proteins encoded by Epstein-Barr virus trans-activator genes depends on the differentiation of epithelial cells in oral hairy leukoplakia.

Authors:  J Becker; U Leser; M Marschall; A Langford; W Jilg; H Gelderblom; P Reichart; H Wolf
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-01       Impact factor: 11.205

7.  Tissue distribution of the C3d/EBV-receptor: CD21 monoclonal antibodies reactive with a variety of epithelial cells, medullary thymocytes, and peripheral T-cells.

Authors:  W Timens; A Boes; H Vos; S Poppema
Journal:  Histochemistry       Date:  1991

8.  Depletion of glycoprotein gp85 from virosomes made with Epstein-Barr virus proteins abolishes their ability to fuse with virus receptor-bearing cells.

Authors:  R S Haddad; L M Hutt-Fletcher
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

9.  Epstein-Barr virus (EBV)-containing nasopharyngeal carcinoma cells express the B-cell activation antigen blast2/CD23 and low levels of the EBV receptor CR2.

Authors:  M Billaud; P Busson; D Huang; N Mueller-Lantzch; G Rousselet; O Pavlish; H Wakasugi; J M Seigneurin; T Tursz; G M Lenoir
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

10.  The systemic distribution of Epstein-Barr virus genomes in fatal post-transplantation lymphoproliferative disorders. An in situ hybridization study.

Authors:  P S Randhawa; R Jaffe; A J Demetris; M Nalesnik; T E Starzl; Y Y Chen; L M Weiss
Journal:  Am J Pathol       Date:  1991-04       Impact factor: 4.307
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