Matthieu Minty1, Thibault Canceill2, Sylvie Lê1, Pauline Dubois2, Oihana Amestoy2, Pascale Loubieres1, Jeffrey E Christensen3, Camille Champion4, Vincent Azalbert3, Estelle Grasset3, Sara Hardy3, Jean-Michel Loubes5, Jean-Philippe Mallet3, François Tercé3, Jean-Noël Vergnes1, Rémy Burcelin3, Matteo Serino6, Franck Diemer7, Vincent Blasco-Baque8. 1. INSERM U1048, F-31432 Toulouse, France, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), F-31432 Toulouse, France; Université Paul Sabatier III (UPS), F-31432 Toulouse, France; CHU Toulouse, Service d'Odontologie Toulouse, F-3100, France. 2. Université Paul Sabatier III (UPS), F-31432 Toulouse, France; CHU Toulouse, Service d'Odontologie Toulouse, F-3100, France. 3. INSERM U1048, F-31432 Toulouse, France, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), F-31432 Toulouse, France; Université Paul Sabatier III (UPS), F-31432 Toulouse, France. 4. INSERM U1048, F-31432 Toulouse, France, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), F-31432 Toulouse, France; Université Paul Sabatier III (UPS), F-31432 Toulouse, France; Institut de Mathématiques de Toulouse, Université de Toulouse, 118, route de Narbonne, F-31062 Toulouse Cedex 9, France. 5. Institut de Mathématiques de Toulouse, Université de Toulouse, 118, route de Narbonne, F-31062 Toulouse Cedex 9, France. 6. IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France. 7. Université Paul Sabatier III (UPS), F-31432 Toulouse, France; CHU Toulouse, Service d'Odontologie Toulouse, F-3100, France; Clément Ader Institute, UMR-CNRS 5312, Toulouse, France. 8. INSERM U1048, F-31432 Toulouse, France, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), F-31432 Toulouse, France; Université Paul Sabatier III (UPS), F-31432 Toulouse, France; CHU Toulouse, Service d'Odontologie Toulouse, F-3100, France. Electronic address: vincent.blasco@inserm.fr.
Abstract
OBJECTIVE: Elite athletes are prone to develop oral diseases, which could increase the risk for injuries. The aim of this study was to evaluate the oral health and the composition of oral microbiota of elite rugby players compared to the general population. METHODS: We set up a case-control study by screening 24 professional rugby players (PRG) and 22 control patients (CG) for dental and gingival examinations and performed a taxonomic analysis and a predicted functional analysis of oral microbiota. RESULTS: The Decay, Missing and Filled (DMF) teeth index (5.54 ± 6.18 versus 2.14 ± 3.01; p = 0.01) and the frequency of gingivitis (58,33% versus 13.63%) were significantly increased in PRG compared to CG. PRG were characterized by a dysbiotic oral microbiota (Shannon Index: 3.32 ± 0.62 in PRG versus 3.79 ± 0.68 in CG; p = 0.03) with an increase of Streptococcus (58.43 ± 16.84 versus 42.60 ± 17.45; p = 0.005), the main genus implicated in caries. Predicted metagenomics of oral microbiota in rugby players was suggestive of a cariogenic metagenome favourable to the development of caries. CONCLUSIONS: Our study shows that the oral health of PRG was poorer than the general population. PRG are characterized by a dysbiotic oral microbiota with an increase of the relative abundance of Streptococcus genus, positively correlated to the weight and negatively correlated to the diversity of oral microbiota. CLINICAL SIGNIFICANCE: Dental screening should be included in the medical follow-up of professional rugby players as a part of their health management. New strategies such as using probiotics like Lactobacillus could help to control the dysbiosis of oral microbiota.
OBJECTIVE: Elite athletes are prone to develop oral diseases, which could increase the risk for injuries. The aim of this study was to evaluate the oral health and the composition of oral microbiota of elite rugby players compared to the general population. METHODS: We set up a case-control study by screening 24 professional rugby players (PRG) and 22 control patients (CG) for dental and gingival examinations and performed a taxonomic analysis and a predicted functional analysis of oral microbiota. RESULTS: The Decay, Missing and Filled (DMF) teeth index (5.54 ± 6.18 versus 2.14 ± 3.01; p = 0.01) and the frequency of gingivitis (58,33% versus 13.63%) were significantly increased in PRG compared to CG. PRG were characterized by a dysbiotic oral microbiota (Shannon Index: 3.32 ± 0.62 in PRG versus 3.79 ± 0.68 in CG; p = 0.03) with an increase of Streptococcus (58.43 ± 16.84 versus 42.60 ± 17.45; p = 0.005), the main genus implicated in caries. Predicted metagenomics of oral microbiota in rugby players was suggestive of a cariogenic metagenome favourable to the development of caries. CONCLUSIONS: Our study shows that the oral health of PRG was poorer than the general population. PRG are characterized by a dysbiotic oral microbiota with an increase of the relative abundance of Streptococcus genus, positively correlated to the weight and negatively correlated to the diversity of oral microbiota. CLINICAL SIGNIFICANCE: Dental screening should be included in the medical follow-up of professional rugby players as a part of their health management. New strategies such as using probiotics like Lactobacillus could help to control the dysbiosis of oral microbiota.
Authors: M Minty; P Loubières; T Canceill; V Azalbert; R Burcelin; F Tercé; V Blasco-Baque Journal: J Physiol Biochem Date: 2020-07-09 Impact factor: 4.158
Authors: Andrea Butera; Simone Gallo; Maurizio Pascadopoli; Giuseppe Alessandro Scardina; Sofia Pezzullo; Andrea Scribante Journal: J Clin Med Date: 2022-08-20 Impact factor: 4.964