Literature DB >> 30292735

A punch in the gut - Intestinal inflammation links environmental factors to neurodegeneration in Parkinson's disease.

Anouck Becker1, Klaus Faßbender1, Wolfgang H Oertel2, Marcus M Unger3.   

Abstract

Parkinson's disease (PD) is an etiologically heterogeneous disorder. Experimental, clinical and epidemiological data suggest that intestinal inflammation contributes to the pathogenesis of PD. This article reviews recent literature on gut microbiota and intestinal inflammation in PD. We propose that intestinal inflammation links environmental factors (e.g. an altered gut microbiota composition) to neurodegeneration in (genetically susceptible) PD patients. In addition, there is an epidemiological and genetic overlap between PD and inflammatory bowel disease. This overlap provides an opportunity to develop new treatment strategies for at least a subgroup of PD patients.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Calprotectin; Crohn's disease; Inflammatory bowel disease; Intestinal inflammation; NOD2; Parkinson's disease; Short chain fatty acids

Mesh：

Year:  2018        PMID： 30292735     DOI： 10.1016/j.parkreldis.2018.09.032

Source DB:  PubMed          Journal:  Parkinsonism Relat Disord        ISSN： 1353-8020            Impact factor:   4.891


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