S Usman1, L Smith2, N Brown3, V Major4. 1. London Northwest NHS Trust, Flat 80 Grand Union Heights, Northwick Road, Wembley, HA0 1LF, United Kingdom. Electronic address: sadiq.usman@nhs.net. 2. Medical Imaging and Radiation Sciences, Allied Health Professions and Midwifery, School of Health and Social Work University of Hertfordshire, College Lane, Hatfield, AL10 9AB, United Kingdom. Electronic address: L.M.Smith@herts.ac.uk. 3. Department of Allied Health and Midwifery School of Health & Social Work University of Hertfordshire, College Lane, Hatfield, Herts, AL10 9AB, United Kingdom. Electronic address: n.2.brown@herts.ac.uk. 4. School of Health and Social Work, University of Hertfordshire, College Lane, Hatfield, Herts, AL10 9AB, United Kingdom. Electronic address: v.major@herts.ac.uk.
Abstract
OBJECTIVES: The aim of this systematic review is to investigate diagnostic accuracy of Magnetic Resonance Imaging (MRI) scans using liver specific tissue contrast media over contrast enhanced Multi Detector CT (MDCT) in diagnoses of Hepatocellular Carcinoma (HCC) in patients with chronic liver disease. KEY FINDINGS: A total of 8 diagnostic studies were identified and generally considered of high quality. The studies reported sufficient evidence on sensitivity and specificity, which was synthesised and summarised providing an overview of the evidence. Findings indicate that MRI scans using liver specific tissue contrast have a better diagnostic performance compared to contrast enhanced MDCT in diagnostic work-up of HCC in patients with chronic liver disease. CONCLUSION: The current review identified sufficient high quality studies reporting statistical difference (P < 0.05), to establish the superiority of gadoxetetic acid enhanced MRI for sensitivity and specificity in comparison to MDCT in the diagnosis of HCC in chronic liver disease.
OBJECTIVES: The aim of this systematic review is to investigate diagnostic accuracy of Magnetic Resonance Imaging (MRI) scans using liver specific tissue contrast media over contrast enhanced Multi Detector CT (MDCT) in diagnoses of Hepatocellular Carcinoma (HCC) in patients with chronic liver disease. KEY FINDINGS: A total of 8 diagnostic studies were identified and generally considered of high quality. The studies reported sufficient evidence on sensitivity and specificity, which was synthesised and summarised providing an overview of the evidence. Findings indicate that MRI scans using liver specific tissue contrast have a better diagnostic performance compared to contrast enhanced MDCT in diagnostic work-up of HCC in patients with chronic liver disease. CONCLUSION: The current review identified sufficient high quality studies reporting statistical difference (P < 0.05), to establish the superiority of gadoxetetic acid enhanced MRI for sensitivity and specificity in comparison to MDCT in the diagnosis of HCC in chronic liver disease.