Elza Cloete1, Frank H Bloomfield2, Lynn Sadler3, Monique W M de Laat3, A Kirsten Finucane4, Thomas L Gentles4. 1. Liggins Institute, University of Auckland, Auckland, New Zealand. Electronic address: e.cloete@auckland.ac.nz. 2. Liggins Institute, University of Auckland, Auckland, New Zealand. 3. Women's Health, Auckland City Hospital, Auckland, New Zealand. 4. Pediatric and Congenital Cardiac Services, Starship Children's Hospital, Auckland, New Zealand.
Abstract
OBJECTIVE: To establish the impact that timing of diagnosis and place of birth have on neonatal outcomes in those with readily treatable critical congenital heart disease. STUDY DESIGN: This was a population-based study with a complete national cohort of live-born infants with transposition of the great arteries and aortic arch obstruction in New Zealand between 2006 and 2014. Timing of diagnosis, place of birth, survival to surgery, in-hospital events, and neonatal mortality were reviewed. Live births with a gestation of ≥35 weeks and without associated major extracardiac anomalies were included for analysis. RESULTS: A total of 166 live-born infants with transposition of the great arteries and 87 with aortic arch obstruction were included. Antenatal detection increased from 32% in the first 3 years to 47% in the last 3 years (P = .05). During the same period, neonatal mortality decreased from 9% to 1% (P = .02). No deaths occurred after surgical intervention. An antenatal diagnosis was associated with decreased mortality (1/97 [1%] vs 11/156 [7%]; P = .03) and birth outside the surgical center was associated with increased risk of mortality (11/147 [7%] vs 1/106 [1%]; P = .02). Those with an antenatal diagnosis required fewer hours of mechanical ventilation (P = .02) and had shorter durations of hospital stay (P = .05) compared with those diagnosed >48 hours after birth. CONCLUSIONS: The mortality risk for transposition of the great arteries and critical aortic arch obstruction is greatest before cardiac surgery. Improved antenatal detection allowing delivery at a surgical center is associated with reduced mortality.
OBJECTIVE: To establish the impact that timing of diagnosis and place of birth have on neonatal outcomes in those with readily treatable critical congenital heart disease. STUDY DESIGN: This was a population-based study with a complete national cohort of live-born infants with transposition of the great arteries and aortic arch obstruction in New Zealand between 2006 and 2014. Timing of diagnosis, place of birth, survival to surgery, in-hospital events, and neonatal mortality were reviewed. Live births with a gestation of ≥35 weeks and without associated major extracardiac anomalies were included for analysis. RESULTS: A total of 166 live-born infants with transposition of the great arteries and 87 with aortic arch obstruction were included. Antenatal detection increased from 32% in the first 3 years to 47% in the last 3 years (P = .05). During the same period, neonatal mortality decreased from 9% to 1% (P = .02). No deaths occurred after surgical intervention. An antenatal diagnosis was associated with decreased mortality (1/97 [1%] vs 11/156 [7%]; P = .03) and birth outside the surgical center was associated with increased risk of mortality (11/147 [7%] vs 1/106 [1%]; P = .02). Those with an antenatal diagnosis required fewer hours of mechanical ventilation (P = .02) and had shorter durations of hospital stay (P = .05) compared with those diagnosed >48 hours after birth. CONCLUSIONS: The mortality risk for transposition of the great arteries and critical aortic arch obstruction is greatest before cardiac surgery. Improved antenatal detection allowing delivery at a surgical center is associated with reduced mortality.
Authors: Elza Cloete; Thomas L Gentles; Lesley A Dixon; Dianne R Webster; Joshua D Agnew; Sarka Davidkova; Jane M Alsweiler; Jenny Rogers; Frank H Bloomfield Journal: BMJ Open Date: 2019-08-18 Impact factor: 2.692
Authors: Elza Cloete; Frank H Bloomfield; Sharnie A Cassells; Monique W M de Laat; Lynn Sadler; Thomas L Gentles Journal: Acta Paediatr Date: 2019-09-02 Impact factor: 2.299
Authors: Elza Cloete; Thomas L Gentles; Dianne R Webster; Sarka Davidkova; Lesley A Dixon; Jane M Alsweiler; Frank H Bloomfield Journal: Acta Paediatr Date: 2019-08-08 Impact factor: 2.299
Authors: Carlijn Lempersz; Lore Noben; Sally-Ann B Clur; Edwin van den Heuvel; Zhouzhao Zhan; Monique Haak; S Guid Oei; Rik Vullings; Judith O E H van Laar Journal: PLoS One Date: 2021-12-16 Impact factor: 3.240