Xinling Qian1, Yuqian Li2, Xiaotian Liu1, Runqi Tu1, Zhongyan Tian1, Haiqing Zhang1, Xia Zhang1, Wen Zhou1, Jingjing Jiang1, Yanhua Wang3, Ronghai Bie4, Chongjian Wang5. 1. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. 2. Department of Clinical Pharmacology, School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, PR China. 3. Department of encephalopathy, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, PR China. 4. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address: bierh2012@126.com. 5. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address: tjwcj2005@126.com.
Abstract
BACKGROUND: The risk allele frequency of rs1378942 of c-src tyrosine kinase (CSK) gene is much higher in Asians (~ 0.80) than that in Europeans (~ 0.35), and the association between rs1378942 and blood pressure is controversial in Asians. Thus, the review and meta-analysis was performed to explore the effects of rs1378942 polymorphism on systolic blood pressure (SBP), diastolic blood pressure (DBP) levels and hypertension in Asians. METHODS: A literature search was conducted in electronic databases up to September 1, 2018. Beta, Odds Ratio (OR) and corresponding 95% confidence intervals (95%CI) were calculated to estimate the effects of rs1378942 on SBP, DBP and hypertension. Quanto software was used to estimate the statistical power. RESULTS: The results showed that the rs1378942 polymorphism significantly affected blood pressure levels in Asians, the C allele carriers had higher SBP and DBP levels: beta (95%CI): 0.71(0.38-1.04), P = 2.579 × 10-5, I2 = 43.5%, and beta (95%CI): 0.33(0.18-0.49), P = 2.092 × 10-5, I2 = 28.3%, respectively. This association was also found in East Asians, but not in South Asians. Furthermore, no significant association was observed with hypertension: OR (95%CI): 1.10 (0.97-1.25), P = .129, I2 = 81.2%. CONCLUSION: The meta-analysis demonstrates that the C allele of the CSK rs1378942 is associated with higher SBP and DBP levels in East Asians.
BACKGROUND: The risk allele frequency of rs1378942 of c-src tyrosine kinase (CSK) gene is much higher in Asians (~ 0.80) than that in Europeans (~ 0.35), and the association between rs1378942 and blood pressure is controversial in Asians. Thus, the review and meta-analysis was performed to explore the effects of rs1378942 polymorphism on systolic blood pressure (SBP), diastolic blood pressure (DBP) levels and hypertension in Asians. METHODS: A literature search was conducted in electronic databases up to September 1, 2018. Beta, Odds Ratio (OR) and corresponding 95% confidence intervals (95%CI) were calculated to estimate the effects of rs1378942 on SBP, DBP and hypertension. Quanto software was used to estimate the statistical power. RESULTS: The results showed that the rs1378942 polymorphism significantly affected blood pressure levels in Asians, the C allele carriers had higher SBP and DBP levels: beta (95%CI): 0.71(0.38-1.04), P = 2.579 × 10-5, I2 = 43.5%, and beta (95%CI): 0.33(0.18-0.49), P = 2.092 × 10-5, I2 = 28.3%, respectively. This association was also found in East Asians, but not in South Asians. Furthermore, no significant association was observed with hypertension: OR (95%CI): 1.10 (0.97-1.25), P = .129, I2 = 81.2%. CONCLUSION: The meta-analysis demonstrates that the C allele of the CSKrs1378942 is associated with higher SBP and DBP levels in East Asians.
Authors: Livia L Camargo; Augusto C Montezano; Misbah Hussain; Yu Wang; Zhiguo Zou; Francisco J Rios; Karla B Neves; Rheure Alves-Lopes; Fazli R Awan; Tomasz J Guzik; Thomas Jensen; Richard C Hartley; Rhian M Touyz Journal: Cardiovasc Res Date: 2022-03-25 Impact factor: 10.787