Chelsea Anderson1, Hazel B Nichols1, Allison M Deal2, Yong-Moon Mark Park3, Dale P Sandler3. 1. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 2. Biostatistics and Clinical Data Management Core, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 3. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
Abstract
BACKGROUND: Cardiovascular disease (CVD) risk is an important health concern among survivors of breast cancer. However, few studies to date have examined whether trajectories of CVD risk and major risk factors are worse among women with a breast cancer diagnosis compared with those without. METHODS: Changes in weight, body mass index, waist circumference, systolic blood pressure, and 10-year CVD risk were compared between women with (813 women) and without (1049 women) an incident breast cancer diagnosis while they were enrolled in the National Institute of Environmental Health Sciences Sister Study cohort. Blood pressure and adiposity measures were collected by trained examiners at an enrollment visit (≥1 year before breast cancer diagnosis) and a second home visit 4 to 11 years later (≥1 year after breast cancer diagnosis). The non-laboratory-based Framingham risk score, a measure of 10-year general CVD risk, was calculated at both the enrollment and second visits. All analyses were stratified by menopausal status at the time of enrollment. RESULTS: Women who were premenopausal at the time of enrollment experienced moderate increases in weight, waist circumference, systolic blood pressure, and CVD risk over the study period. Those who were postmenopausal at the time of enrollment demonstrated little change in weight, but were found to have increases in waist circumference, systolic blood pressure, and CVD risk. In both groups, changes over time did not differ significantly according to breast cancer status. Neither chemotherapy nor endocrine therapy were found to be associated with greater increases in CVD risk or risk factors. CONCLUSIONS: In the current study cohort, changes over time in CVD risk, adiposity measures, and blood pressure were similar between women who developed an incident breast cancer and those who did not.
BACKGROUND:Cardiovascular disease (CVD) risk is an important health concern among survivors of breast cancer. However, few studies to date have examined whether trajectories of CVD risk and major risk factors are worse among women with a breast cancer diagnosis compared with those without. METHODS: Changes in weight, body mass index, waist circumference, systolic blood pressure, and 10-year CVD risk were compared between women with (813 women) and without (1049 women) an incident breast cancer diagnosis while they were enrolled in the National Institute of Environmental Health Sciences Sister Study cohort. Blood pressure and adiposity measures were collected by trained examiners at an enrollment visit (≥1 year before breast cancer diagnosis) and a second home visit 4 to 11 years later (≥1 year after breast cancer diagnosis). The non-laboratory-based Framingham risk score, a measure of 10-year general CVD risk, was calculated at both the enrollment and second visits. All analyses were stratified by menopausal status at the time of enrollment. RESULTS:Women who were premenopausal at the time of enrollment experienced moderate increases in weight, waist circumference, systolic blood pressure, and CVD risk over the study period. Those who were postmenopausal at the time of enrollment demonstrated little change in weight, but were found to have increases in waist circumference, systolic blood pressure, and CVD risk. In both groups, changes over time did not differ significantly according to breast cancer status. Neither chemotherapy nor endocrine therapy were found to be associated with greater increases in CVD risk or risk factors. CONCLUSIONS: In the current study cohort, changes over time in CVD risk, adiposity measures, and blood pressure were similar between women who developed an incident breast cancer and those who did not.
Authors: Maureen Sadim; Yanfei Xu; Katharina Selig; Julie Paulus; Regina Uthe; Surbhi Agarwl; Iram Dubin; Panagiota Oikonomopoulou; Lesya Zaichenko; Silvia Aki McCandlish; Linda Van Horn; Christos Mantzoros; Donna Pauler Ankerst; Virginia G Kaklamani Journal: Cancer Date: 2017-02-14 Impact factor: 6.860
Authors: Ralph B D'Agostino; Ramachandran S Vasan; Michael J Pencina; Philip A Wolf; Mark Cobain; Joseph M Massaro; William B Kannel Journal: Circulation Date: 2008-01-22 Impact factor: 29.690
Authors: R J Freedman; N Aziz; D Albanes; T Hartman; D Danforth; S Hill; N Sebring; J C Reynolds; J A Yanovski Journal: J Clin Endocrinol Metab Date: 2004-05 Impact factor: 5.958
Authors: Na-Jin Park; Yuefang Chang; Catherine Bender; Yvette Conley; Rowan T Chlebowski; G J van Londen; Randi Foraker; Sylvia Wassertheil-Smoller; Marcia L Stefanick; Lewis H Kuller Journal: PLoS One Date: 2017-09-21 Impact factor: 3.240
Authors: M M G A van den Berg; R M Winkels; J Th C M de Kruif; H W M van Laarhoven; M Visser; J H M de Vries; Y C de Vries; E Kampman Journal: BMC Cancer Date: 2017-04-12 Impact factor: 4.430
Authors: Dale P Sandler; M Elizabeth Hodgson; Sandra L Deming-Halverson; Paula S Juras; Aimee A D'Aloisio; Lourdes M Suarez; Cynthia A Kleeberger; David L Shore; Lisa A DeRoo; Jack A Taylor; Clarice R Weinberg Journal: Environ Health Perspect Date: 2017-12-20 Impact factor: 9.031
Authors: Xiaochen Zhang; Meghan Pawlikowski; Susan Olivo-Marston; Karen Patricia Williams; Julie K Bower; Ashley S Felix Journal: PLoS One Date: 2021-03-04 Impact factor: 3.240
Authors: Qingqing Hu; Chun-Pin Chang; Kerry Rowe; John Snyder; Vikrant Deshmukh; Michael Newman; Alison Fraser; Ken Smith; Lisa H Gren; Christina Porucznik; Joseph B Stanford; David Gaffney; N Lynn Henry; Ivette Lopez; Mia Hashibe Journal: JNCI Cancer Spectr Date: 2021-02-15