Karnika Ayinapudi1, Twinkle Singh1, Ayush Motwani1, Thierry H Le Jemtel2, Suzanne Oparil3. 1. Tulane University Heart and Vascular Institute, 1430 Tulane Ave, SL-48, New Orleans, LA, 70112, USA. 2. Tulane University Heart and Vascular Institute, 1430 Tulane Ave, SL-48, New Orleans, LA, 70112, USA. lejemtel@tulane.edu. 3. Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Abstract
PURPOSE OF REVIEW: Whether the present obesity epidemic will increase the prevalence of pulmonary hypertension over the next decades is unclear. We review the obesity-related mechanisms that may further the development and progression of pulmonary hypertension. RECENT FINDINGS: Systemic and local inflammation, insulin resistance and oxidative stress contribute to the pathobiology of obesity and pulmonary arterial hypertension. Preliminary data suggest that expansion of adipose tissue surrounding the pulmonary artery may hasten the progression of pulmonary arterial hypertension in obese persons. Further, obesity-associated cardiac and pulmonary conditions may increase the prevalence of groups 2 and 3 pulmonary hypertension. The obesity epidemic is likely to increase the prevalence of pulmonary arterial hypertension by enabling vascular remodeling. Obesity-associated cardiac and pulmonary conditions will increase pulmonary hypertension prevalence.
PURPOSE OF REVIEW: Whether the present obesity epidemic will increase the prevalence of pulmonary hypertension over the next decades is unclear. We review the obesity-related mechanisms that may further the development and progression of pulmonary hypertension. RECENT FINDINGS: Systemic and local inflammation, insulin resistance and oxidative stress contribute to the pathobiology of obesity and pulmonary arterial hypertension. Preliminary data suggest that expansion of adipose tissue surrounding the pulmonary artery may hasten the progression of pulmonary arterial hypertension in obesepersons. Further, obesity-associated cardiac and pulmonary conditions may increase the prevalence of groups 2 and 3 pulmonary hypertension. The obesity epidemic is likely to increase the prevalence of pulmonary arterial hypertension by enabling vascular remodeling. Obesity-associated cardiac and pulmonary conditions will increase pulmonary hypertension prevalence.
Authors: Christoph A Kauppert; Iris Dvorak; Florian Kollert; Frank Heinemann; Rudolf A Jörres; Michael Pfeifer; Stephan Budweiser Journal: Respir Med Date: 2013-09-28 Impact factor: 3.415
Authors: Aljohara S Almeneessier; Samar Z Nashwan; Mostafa Q Al-Shamiri; Seithikurippu R Pandi-Perumal; Ahmed S BaHammam Journal: J Thorac Dis Date: 2017-03 Impact factor: 2.895
Authors: John A Heit; Aneel Ashrani; Daniel J Crusan; Robert D McBane; Tanya M Petterson; Kent R Bailey Journal: Thromb Haemost Date: 2016-12-15 Impact factor: 5.249
Authors: Mitsugu Shimobayashi; Verena Albert; Bettina Woelnerhanssen; Irina C Frei; Diana Weissenberger; Anne Christin Meyer-Gerspach; Nicolas Clement; Suzette Moes; Marco Colombi; Jerome A Meier; Marta M Swierczynska; Paul Jenö; Christoph Beglinger; Ralph Peterli; Michael N Hall Journal: J Clin Invest Date: 2018-03-12 Impact factor: 14.808
Authors: Srinivas Rajsheker; David Manka; Andra L Blomkalns; Tapan K Chatterjee; Lynn L Stoll; Neal L Weintraub Journal: Curr Opin Pharmacol Date: 2010-01-07 Impact factor: 5.547
Authors: Benjamin T Suratt; Niki D J Ubags; Deepa Rastogi; Kelan G Tantisira; Benjamin J Marsland; Irina Petrache; Janice B Allen; Jason H T Bates; Fernando Holguin; Meredith C McCormack; Evangelos D Michelakis; Stephen M Black; Manu Jain; Ana L Mora; Viswanathan Natarajan; Yury I Miller; Michael B Fessler; Konstantin G Birukov; Ross S Summer; Stephanie A Shore; Anne E Dixon Journal: Ann Am Thorac Soc Date: 2017-06
Authors: Bryce N Balmain; Quinn M Halverson; Andrew R Tomlinson; Timothy Edwards; Matthew S Ganio; Tony G Babb Journal: Ann Am Thorac Soc Date: 2021-07
Authors: Juan F Masa; Iván D Benítez; Shahrokh Javaheri; Maria Victoria Mogollon; Maria Á Sánchez-Quiroga; Francisco J Gomez de Terreros; Jaime Corral; Rocio Gallego; Auxiliadora Romero; Candela Caballero-Eraso; Estrella Ordax-Carbajo; María F Troncoso; Mónica González; Soledad López-Martín; José M Marin; Sergi Martí; Trinidad Díaz-Cambriles; Eusebi Chiner; Carlos Egea; Javier Barca; Ferrán Barbé; Babak Mokhlesi Journal: J Clin Sleep Med Date: 2022-04-01 Impact factor: 4.062
Authors: Matthew D Spencer; Bryce N Balmain; Vipa Bernhardt; Daniel P Wilhite; Tony G Babb Journal: Respir Physiol Neurobiol Date: 2021-02-11 Impact factor: 1.931
Authors: Eduardo De la Cruz-Cano; Cristina Del C Jiménez-González; José A Díaz-Gandarilla; Carlos J López-Victorio; Adelma Escobar-Ramírez; Sheila A Uribe-López; Elizabeth Huerta-García; Jorge-Tonatiuh Ayala-Sumuano; Vicente Morales-García; Liliana Gútierrez-López; José A González-Garrido Journal: F1000Res Date: 2022-01-06
Authors: Timothy E Thayer; Rebecca T Levinson; Shi Huang; Tufik Assad; Eric Farber-Eger; Quinn S Wells; Jonathan D Mosley; Evan L Brittain Journal: Chest Date: 2020-07-24 Impact factor: 9.410