Literature DB >> 30291356

Author Correction: Parent-of-origin-specific signatures of de novo mutations.

Jakob M Goldmann1, Wendy S W Wong2, Michele Pinelli3, Terry Farrah4, Dale Bodian2, Anna B Stittrich4, Gustavo Glusman4, Lisenka E L M Vissers5, Alexander Hoischen5, Jared C Roach4, Joseph G Vockley2,6, Joris A Veltman5,7, Benjamin D Solomon2,8,9, Christian Gilissen10, John E Niederhuber11,12.   

Abstract

In the version of this article published, the P values for the enrichment of single mutation categories were inadvertently not corrected for multiple testing. After multiple-testing correction, only two of the six mutation categories mentioned are still statistically significant. To reflect this, the text "More specifically, paternally derived DNMs are enriched in transitions in A[.]G contexts, especially ACG>ATG and ATG>ACG (Bonferroni-corrected P = 1.3 × 10-2 and P = 1 × 10-3, respectively). Additionally, we observed overrepresentation of ATA>ACA mutations (Bonferroni-corrected P = 4.28 × 10-2) for DNMs of paternal origin. Among maternally derived DNMs, CCA>CTA, GCA>GTA and TCT>TGT mutations were significantly overrepresented (Bonferroni-corrected P = 4 × 10-4, P = 5 × 10-4, P = 1 × 10-3, respectively)" should read "More specifically, CCA>CTA and GCA>GTA mutations were significantly overenriched on the maternal allele (Bonferroni-corrected P = 0.0192 and P = 0.048, respectively)." Additionally, the last sentence to the legend for Fig. 3b should read "Green boxes highlight the mutation categories that differ significantly" instead of "Green boxes highlight the mutation categories that differ more than 1% of mutation load with a bootstrapping P value <0.05." Corrected versions of Fig. 3b and Supplementary Table 25 appear with the Author Correction.

Entities:  

Year:  2018        PMID: 30291356     DOI: 10.1038/s41588-018-0226-5

Source DB:  PubMed          Journal:  Nat Genet        ISSN: 1061-4036            Impact factor:   38.330


  3 in total

Review 1.  Advanced Paternal Age and Future Generations.

Authors:  Peter T K Chan; Bernard Robaire
Journal:  Front Endocrinol (Lausanne)       Date:  2022-06-09       Impact factor: 6.055

2.  Patterns and distribution of de novo mutations in multiplex Middle Eastern families.

Authors:  Muhammad Kohailan; Waleed Aamer; Najeeb Syed; Sujitha Padmajeya; Sura Hussein; Amira Sayed; Jyothi Janardhanan; Sasirekha Palaniswamy; Nady El Hajj; Ammira Al-Shabeeb Akil; Khalid A Fakhro
Journal:  J Hum Genet       Date:  2022-06-20       Impact factor: 3.755

Review 3.  [Twin research in Germany].

Authors:  Paul Enck; Miriam Goebel-Stengel; Olaf Rieß; Jeannette Hübener-Schmid; Karl Oliver Kagan; Andreas Michael Nieß; Henning Tümmers; Urban Wiesing; Stephan Zipfel; Andreas Stengel
Journal:  Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz       Date:  2021-09-15       Impact factor: 1.513

  3 in total

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