Transcranial direct current stimulation modulates the brain's response to foot stimuli under dual-task condition: A fMRI study in elderly adults.

Previous behavioral studies have shown that high-intensity cognitive tasks weaken balance control in elder adults. Moreover, age-related loss of plantar sensation is considered to be an important contributing factor to the occurrence of falls. Recently, we have realized that transcranial direct current stimulation (tDCS) can effectively improve the balance of the elderly under the dual-task, but its underlying regulatory mechanism is not clear. In this study, task functional Magnetic Resonance Imaging (fMRI) was used to study the brain's response to foot stimuli under foot stimuli or dual-task (foot stimuli and cognitive task) conditions to explain the effect of the addition of cognitive tasks during balance in 16 healthy elderly adults. To study whether tDCS would counteract the effect of the added cognitive task, we further compared the differences in activity of the cerebral cortices of dual-task and tDCS-dual-task conditions. The results suggested added cognitive tasks significantly attenuated the response of the brain to foot stimuli in elderly adults. Moreover, the cortex excitability weakened by cognitive tasks was significantly promoted after 20 min of tDCS. In conclusion, a portion of the resources originally used for plantar sensory processing may be assigned to the processing of the cognitive task when the cognitive tasks are added, which results in insufficient resources for plantar sensory processing. tDCS improves the ability of the brain to respond to foot stimuli by modulating the excitability of the cognitive cortex and reverses the effects of cognitive tasks.