Literature DB >> 30289085

Potential Impact of MicroRNA-423 Gene Variability in Coronary Artery Disease.

Chandan K Jha1, Rashid Mir2, Imadeldin Elfaki3, Naina Khullar4, Suriya Rehman5, Jamsheed Javid2, Shaheena Banu6, Sukh Mohinder Singh Chahal1.   

Abstract

AIM: Studies have evaluated the association of miRNA-423 C>A genotyping with the susceptibility to various diseases such cancers, atherosclerosis and inflammatory bowel disease but the results were contradictory. However, no studies have reported the association between miRNA-423 rs6505162 C>A polymorphism and susceptibility of coronary artery disease. MicroRNAs regulate expression of multiple genes involved in atherogenesis. Therefore, we investigated the association of microRNA-423C>T gene variations with susceptibility to coronary artery disease.
METHODOLOGY: This study was conducted on 100 coronary artery disease patients and 117 matched healthy controls. The genotyping of the microRNA-423 rs6505162C>A was performed by using Amplification refractory mutation system PCR method (ARMS-PCR).
RESULTS: A significant difference was observed in the genotype distribution among the coronary artery disease cases and sex-matched healthy controls (P=0.048). The frequencies of all three genotypes CC, CA, AA reported in the patient's samples were 55%, 41% and 4% and in the healthy controls samples were 55%, 41% and 4% respectively. Our findings showed that the microRNA-423 C>A variant was associated with an increased risk of coronary artery disease in codominant model (OR = 1.96, 95 % CI, 1.12-3.42; RR 1.35(1.05-1.75, p=0.017) of microRNA-423CA genotype and significant association in dominant model (OR 1.97, 95% CI (1.14-3.39), (CA+AA vs CC) and non-significant association for recessive model (OR=1.42, 95%CI=0.42-4.83, P=0.56, AA vs CC+CA).While, the A allele significantly increased the risk of coronary artery disease (OR =1.56, 95 % CI, 1.03-2.37; p=0.035) compared to C allele. Therefore, it was observed that more than 1.96, 1.97 and 1.56 fold increased risk of developing coronary artery disease.
CONCLUSION: Our findings indicated that microRNA-423 CA genotype and A allele are associated with an increased susceptibility to Coronary artery disease. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Entities:  

Keywords:  Amplificationzzm321990refractory mutation system PCR method (ARMS-PCR); MicroRNA-423; cerebrovascular disease; congenital heart disease (CHD); coronary artery disease (CAD); genotype; polymorphism.

Mesh：

Substances：

Year:  2019        PMID： 30289085     DOI： 10.2174/1871530318666181005095724

Source DB:  PubMed          Journal:  Endocr Metab Immune Disord Drug Targets        ISSN： 1871-5303            Impact factor:   2.895


  9 in total

1.  Molecular Determination of Vascular Endothelial Growth Factor, miRNA-423 Gene Abnormalities by Utilizing ARMS-PCR and Their Association with Fetal Hemoglobin Expression in the Patients with Sickle Cell Disease.

Authors:  Abdullah Hamadi; Rashid Mir; Ali Mahzari; Abdulrahim Hakami; Reema Almotairi; Gasim Dobie; Fawaz Hamdi; Mohammed Hassan Nahari; Razan Alhefzi; Mohammed Alasseiri; Nora Y Hakami; Hadeel Al Sadoun; Osama M Al-Amer; Jameel Barnawi; Hassan A Madkhali
Journal:  Curr Issues Mol Biol       Date:  2022-06-01       Impact factor: 2.976

2.  Clinical Implications of Krüpple-like Transcription Factor KLF-14 and Certain Micro-RNA (miR-27a, miR-196a2, miR-423) Gene Variations as a Risk Factor in the Genetic Predisposition to PCOS.

Authors:  Rashid Mir; Nizar H Saeedi; Mohammed M Jalal; Malik A Altayar; Jameel Barnawi; Abdullah Hamadi; Faris J Tayeb; Sanad E Alshammari; Nabil Mtiraoui; Mohammed Eltigani M Ali; Faisel M Abuduhier; Mohammad Fahad Ullah
Journal:  J Pers Med       Date:  2022-04-06

3.  Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study.

Authors:  Chandan K Jha; Rashid Mir; Imadeldin Elfaki; Jamsheed Javid; Abdullatif Taha Babakr; Shaheena Banu; S M S Chahal
Journal:  J Pers Med       Date:  2019-06-06

Review 4.  Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease.

Authors:  Imadeldin Elfaki; Rashid Mir; Mohammad Muzaffar Mir; Faisel M AbuDuhier; Abdullatif Taha Babakr; Jameel Barnawi
Journal:  J Pers Med       Date:  2019-11-25

5.  Protective effect of microRNA‑381 against inflammatory damage of endothelial cells during coronary heart disease by targeting CXCR4.

Authors:  Yimin Li; Jin Huang; Hong Yan; Xiangyu Li; Chang Ding; Qian Wang; Zhiping Lu
Journal:  Mol Med Rep       Date:  2020-01-22       Impact factor: 2.952

6.  Genetic Variants of MicroRNA and DROSHA Genes in Association With the Risk of Tuberculosis in the Amazon Population.

Authors:  Diana Feio da Veiga Borges Leal; Mayara Natália Santana da Silva; Lucas Favacho Pastana; Marianne Rodrigues Fernandes; Aidalucy do Socorro Costa de Athayde; Débora Christina Ricardo Fernandes Porchera; Cleonardo Augusto da Silva; Antônio André Conde Modesto; Paulo Pimentel De Assumpcão; Sidney Emanuel Batista Dos Santos; Ney Pereira Carneiro Dos Santos
Journal:  Front Genet       Date:  2022-03-02       Impact factor: 4.599

7.  Potential impact of GCK, MIR-196A-2 and MIR-423 gene abnormalities on the development and progression of type 2 diabetes mellitus in Asir and Tabuk regions of Saudi Arabia.

Authors:  Mohammad Muzaffar Mir; Rashid Mir; Mushabab Ayed Abdullah Alghamdi; Javed Iqbal Wani; Imadeldin Elfaki; Zia Ul Sabah; Muhanad Alhujaily; Mohammed Jeelani; Vijaya Marakala; Muffarah Hamid Alharthi; Abdullah M Al-Shahrani
Journal:  Mol Med Rep       Date:  2022-03-16       Impact factor: 2.952

8.  Severe COVID-19 Pneumonia and Genetic Susceptibility: A Case Report and Literature Review.

Authors:  Badr A Alsayed; Rashid Mir
Journal:  Cureus       Date:  2022-03-30

9.  Differential impact of the angiotensin-converting enzyme-2 (ACE2 rs4343 G>A) and miR-196a2 rs11614913 C>T gene alterations in COVID-19 disease severity and mortality.

Authors:  Mohammad Muzaffar Mir; Rashid Mir; Mushabab Ayed Abdullah Alghamdi; Badr Abdulmohsin Alsayed; Imadeldin Elfaki; Ali Al Bshabshe; Rabia Farooq; Muhanad Alhujaily; Muffarah Hamid Alharthi; Mohannad Mohammad S Alamri; Abdullah M Al-Shahrani
Journal:  Exp Ther Med       Date:  2022-04-29       Impact factor: 2.447
  9 in total

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