Literature DB >> 30287437

Spontaneous splenic rupture secondary to dabigatran: the last in a series of unfortunate events.

Rachel Carey1, Varun Nelatur2.   

Abstract

We present the case of a 77-year-old woman who had an accidental fall in her garden, resulting in a fracture of her left ankle. After manipulation of the fracture, she developed sudden onset shortness of breath. An echo led to the diagnosis of Takotsubo cardiomyopathy. Shortly after this she developed sudden onset receptive and expressive dysphasia. Magnetic resonance imaging (MRI) of the head confirmed a left parietal infarct thought to be secondary to left ventricular thrombus formation. She was started on dabigatran. A few days later, she developed abdominal pain, and was subsequently diagnosed with a spontaneous splenic rupture. This case was interesting due to the unusual chain of events following a simple fall, and also a rare complication of anticoagulant therapy. © Royal College of Physicians 2018. All rights reserved.

Entities:  

Keywords:  Anticoagulation; Takotsubo; side effect; splenic rupture; thrombus

Mesh:

Substances:

Year:  2018        PMID: 30287437      PMCID: PMC6334098          DOI: 10.7861/clinmedicine.18-5-406

Source DB:  PubMed          Journal:  Clin Med (Lond)        ISSN: 1470-2118            Impact factor:   2.659


  5 in total

Review 1.  Systematic review of atraumatic splenic rupture.

Authors:  P Renzulli; A Hostettler; A M Schoepfer; B Gloor; D Candinas
Journal:  Br J Surg       Date:  2009-10       Impact factor: 6.939

2.  Stress-induced thrombus: prevalence of thromboembolic events and the role of anticoagulation in Takotsubo cardiomyopathy.

Authors:  Mark R Heckle; Cody W McCoy; Oluwaseun A Akinseye; Rami N Khouzam
Journal:  Ann Transl Med       Date:  2018-01

3.  Left Ventricular Thrombi in Takotsubo Syndrome: Incidence, Predictors, and Management: Results From the GEIST (German Italian Stress Cardiomyopathy) Registry.

Authors:  Francesco Santoro; Thomas Stiermaier; Nicola Tarantino; Luisa De Gennaro; Christian Moeller; Francesca Guastafierro; Maria Francesca Marchetti; Roberta Montisci; Elena Carapelle; Tobias Graf; Pasquale Caldarola; Holger Thiele; Matteo Di Biase; Natale Daniele Brunetti; Ingo Eitel
Journal:  J Am Heart Assoc       Date:  2017-12-04       Impact factor: 5.501

4.  Non-traumatic splenic rupture in a patient on oral anticoagulation.

Authors:  Marije M de Kubber; Lucia Jm Kroft; Bas de Groot
Journal:  Int J Emerg Med       Date:  2013-05-21

5.  Spontaneous splenic rupture associated with apixaban: a case report.

Authors:  Lacy E Lowry; Jonathan A Goldner
Journal:  J Med Case Rep       Date:  2016-08-09
  5 in total
  2 in total

1.  Splenic rupture.

Authors:  David Fegan
Journal:  Clin Med (Lond)       Date:  2019-03       Impact factor: 2.659

2.  Atraumatic splenic rupture associated with apixaban.

Authors:  Sijan Basnet; Elan Mohanty; Izza Mir; Rashmi Dhital; Ajay Koirala; Niranjan Tachamo
Journal:  SAGE Open Med Case Rep       Date:  2019-02-21
  2 in total

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