| Literature DB >> 30287212 |
Luis L P daSilva1, Gonzalo A Mardones2.
Abstract
Nef is a major pathogenic factor of human and simian immunodeficiency viruses that hijacks protein trafficking through physical interaction with vesicle coats. This alters the subcellular localization of proteins involved in immunity and neutralizes their function. Understanding the structural bases for these interactions could reveal new targets for antiviral intervention.Entities:
Keywords: AP-1; HIV; MHC-I; Nef; SIV; tetherin
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Year: 2018 PMID： 30287212 DOI： 10.1016/j.tim.2018.09.003
Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079