Nicolas W Shammas1, Anthony Pucillo2, J Stephen Jenkins3, Lawrence A Garcia4, Tom Davis5, Herbert D Aronow6, Ehrin J Armstrong7, Thomas Zeller8, Dierk Scheinert9, Uri Rosenschein10, William Gray11. 1. Midwest Cardiovascular Research Foundation, Davenport, Iowa. Electronic address: shammas@mchsi.com. 2. Division of Cardiology, Columbia Presbyterian, New York, New York. 3. Division of Cardiology, Ochsner Medical Center, New Orleans, Louisiana. 4. Division of Cardiology, St. Elizabeth's Medical Center, Steward Health Care, Boston, Massachusetts. 5. Division of Cardiology, St. John Hospital and Medical Center, Detroit, Michigan. 6. Division of Cardiology, Lifespan Cardiovascular Institute, Providence, Rhode Island. 7. Division of Cardiology, University of Colorado, Aurora, Colorado. 8. Division of Cardiology, Universitaets-Herzzentrum Freiburg - Bad Krozingen, Bad Krozingen, Germany. 9. Division of Cardiology, Leipzig University Hospital, Leipzig, Germany. 10. Division of Cardiology, Bnai Zion Medical Center, Haifa, Israel. 11. Division of Cardiology, Lankenau Heart Institute, Wynnewood, Pennsylvania.
Abstract
OBJECTIVES: The WISE LE (WIRION™ EPS in Lower Extremities Arteries) study was designed to assess the clinical performance of the WIRION Embolic Protection System (EPS) in subjects undergoing lower extremity atherectomy for the treatment of peripheral artery disease. BACKGROUND: Embolization is ubiquitous during endovascular procedures for lower extremity peripheral artery disease. METHODS: The WISE LE was a multicenter study, performed in the United States and Germany. The primary endpoint was freedom from major adverse events (MAEs) occurring within 30 days post-procedure and was compared with an objective performance goal derived from historical atherectomy trials. MAE was defined as a serious adverse event that resulted in death, acute myocardial infarction, thrombosis, pseudoaneurysm, dissection (grade C or greater), or clinical perforation at the filter location, clinically relevant distal embolism, unplanned amputation, or clinically driven target vessel revascularization. The study also included a histopathological analysis of debris captured by the filter during the procedures. RESULTS: The study protocol specified enrollment of 153 patients with the primary endpoint successfully met if 18 (12.0%) or fewer MAEs occurred. A pre-specified interim analysis performed after 103 patients revealed only 2 MAEs, and the study was stopped because it had met its pre-determined metric for success. Lesion deemed not accessible by the WIRION EPS occurred in 7 patients. Debris of <1-mm, 1- to 2-mm, and >2-mm diameter were found in 98%, 22%, and 9% of patients, respectively. CONCLUSIONS: The WIRION EPS is safe and noninferior to the pre-specified performance goal in capturing debris in the vast majority of patients and with the use of a broad range of atherectomy systems.
OBJECTIVES: The WISE LE (WIRION™ EPS in Lower Extremities Arteries) study was designed to assess the clinical performance of the WIRION Embolic Protection System (EPS) in subjects undergoing lower extremity atherectomy for the treatment of peripheral artery disease. BACKGROUND: Embolization is ubiquitous during endovascular procedures for lower extremity peripheral artery disease. METHODS: The WISE LE was a multicenter study, performed in the United States and Germany. The primary endpoint was freedom from major adverse events (MAEs) occurring within 30 days post-procedure and was compared with an objective performance goal derived from historical atherectomy trials. MAE was defined as a serious adverse event that resulted in death, acute myocardial infarction, thrombosis, pseudoaneurysm, dissection (grade C or greater), or clinical perforation at the filter location, clinically relevant distal embolism, unplanned amputation, or clinically driven target vessel revascularization. The study also included a histopathological analysis of debris captured by the filter during the procedures. RESULTS: The study protocol specified enrollment of 153 patients with the primary endpoint successfully met if 18 (12.0%) or fewer MAEs occurred. A pre-specified interim analysis performed after 103 patients revealed only 2 MAEs, and the study was stopped because it had met its pre-determined metric for success. Lesion deemed not accessible by the WIRION EPS occurred in 7 patients. Debris of <1-mm, 1- to 2-mm, and >2-mm diameter were found in 98%, 22%, and 9% of patients, respectively. CONCLUSIONS: The WIRION EPS is safe and noninferior to the pre-specified performance goal in capturing debris in the vast majority of patients and with the use of a broad range of atherectomy systems.
Authors: Nicolas W Shammas; Bhaskar Purushottam; W John Shammas; Lori Christensen; Gail Shammas; Desyree Weakley; Sue Jones-Miller Journal: Vasc Health Risk Manag Date: 2022-08-02