Sara G Aguilar-Navarro1, Alberto J Mimenza-Alvarado2, Alberto A Palacios-García3, Alejandra Samudio-Cruz4, Lidia A Gutiérrez-Gutiérrez3, José A Ávila-Funes5. 1. Departamento de Geriatría, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México. Electronic address: sgan30@hotmail.com. 2. Departamento de Geriatría, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México. 3. Departamento de Neurología y Psiquiatría, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México. 4. Facultad de Psicología Universidad Nacional Autónoma de México, Ciudad de México, México. 5. Departamento de Geriatría, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México; Centre de recherche INSERM, Burdeos, Francia.
Abstract
OBJECTIVE: To establish the validity and reliability of the Montreal Cognitive Assessment in Spanish (MoCA-S) to identify mild cognitive impairment (MCI) and dementia in the Mexican elderly population. MATERIAL AND METHODS: 168 participants from a memory clinic in Mexico City were enrolled and divided into 3 groups: 59 cognitively healthy (CHG), 52 with mild cognitive impairment (MCI) (DSM-5 criteria) and 57 with dementia (NINCDS-ADRDA criteria). The MoCA-S and Mini-Mental State Evaluation (MMSE) were applied at baseline and during the last months to establish intra-observer reliability. ROC curves and a multinomial regression model were constructed to evaluate the effect of age and education on MoCA-S performance. RESULTS: The mean age of the participants was 76±8.1 years and the education rate was 10.7±5.2. The MoCA-S scores by group were: CHG, 27.3±1.9; MCI, 22.9±2.9; and dementia, 13.7±4.9 (p<0.001). The reliability of the MoCA-S was 0.89 and the intraclass correlation coefficient was 0.955. Sensitivity was 80% and specificity was 75%, with a cut-off point of 26 points for MCI (area under the curve, 0.886; p<0.001). For the dementia group, the sensitivity was 98% and specificity was 93%, with a cut-off point of 24points (area under the curve, 0.998; p<0.001). The multinomial regression showed no association with education and age for both the MCI and dementia groups. CONCLUSIONS: The MoCA-S is a valid and reliable instrument for MCI and dementia screening in the Mexican population, even after adjusting for age and education.
OBJECTIVE: To establish the validity and reliability of the Montreal Cognitive Assessment in Spanish (MoCA-S) to identify mild cognitive impairment (MCI) and dementia in the Mexican elderly population. MATERIAL AND METHODS: 168 participants from a memory clinic in Mexico City were enrolled and divided into 3 groups: 59 cognitively healthy (CHG), 52 with mild cognitive impairment (MCI) (DSM-5 criteria) and 57 with dementia (NINCDS-ADRDA criteria). The MoCA-S and Mini-Mental State Evaluation (MMSE) were applied at baseline and during the last months to establish intra-observer reliability. ROC curves and a multinomial regression model were constructed to evaluate the effect of age and education on MoCA-S performance. RESULTS: The mean age of the participants was 76±8.1 years and the education rate was 10.7±5.2. The MoCA-S scores by group were: CHG, 27.3±1.9; MCI, 22.9±2.9; and dementia, 13.7±4.9 (p<0.001). The reliability of the MoCA-S was 0.89 and the intraclass correlation coefficient was 0.955. Sensitivity was 80% and specificity was 75%, with a cut-off point of 26 points for MCI (area under the curve, 0.886; p<0.001). For the dementia group, the sensitivity was 98% and specificity was 93%, with a cut-off point of 24points (area under the curve, 0.998; p<0.001). The multinomial regression showed no association with education and age for both the MCI and dementia groups. CONCLUSIONS: The MoCA-S is a valid and reliable instrument for MCI and dementia screening in the Mexican population, even after adjusting for age and education.
Authors: Sebastian Bello-Lepe; María Francisca Alonso-Sánchez; Alonso Ortega; Marcelo Gaete; Marcela Veliz; Juan Lira; Claudia Paz Perez Salas Journal: Dement Geriatr Cogn Dis Extra Date: 2020-10-14
Authors: Sara G Aguilar-Navarro; Itzel I Gonzalez-Aparicio; José Alberto Avila-Funes; Teresa Juárez-Cedillo; Teresa Tusié-Luna; Alberto Jose Mimenza-Alvarado Journal: Brain Sci Date: 2021-01-07
Authors: Jesus Calderon-Villalon; Gabriel Ramirez-Garcia; Juan Fernandez-Ruiz; Fernanda Sangri-Gil; Aurelio Campos-Romo; Victor Galvez Journal: PLoS One Date: 2021-03-24 Impact factor: 3.240
Authors: Pablo F Belaunzarán-Zamudio; Ana M Ortega-Villa; Alberto J Mimenza-Alvarado; Paola Del Carmen Guerra-De-Blas; Sara G Aguilar-Navarro; Jesús Sepúlveda-Delgado; Sally Hunsberger; Raydel Valdés Salgado; José Ramos-Castañeda; Héctor Armando Rincón León; Paul Rodríguez de La Rosa; José Gabriel Nájera Cancino; John Beigel; Sandra Caballero Sosa; Emilia Ruiz Hernández; John H Powers; Guillermo M Ruiz-Palacios; Clifford Lane Journal: Front Neurol Date: 2021-03-22 Impact factor: 4.003
Authors: Ana M Rodríguez-Salgado; Jorge J Llibre-Guerra; Elena Tsoy; Ana Ibis Peñalver-Guia; Giosmany Bringas; Sabrina J Erlhoff; Joel H Kramer; Isabel Elaine Allen; Victor Valcour; Bruce L Miller; Juan J Llibre-Rodríguez; Katherine L Possin Journal: J Alzheimers Dis Date: 2021 Impact factor: 4.472