Literature DB >> 30286703

Ergothioneine production with Aspergillus oryzae.

Shun Takusagawa1, Yasuharu Satoh2, Iwao Ohtsu3, Tohru Dairi2.   

Abstract

To establish a reliable and practical ergothioneine (ERG) supply, we employed fermentative ERG production using Aspergillus oryzae, a fungus used for food production. We heterologously overexpressed the egt-1 and -2 genes of Neurospora crassa in A. oryzae and succeeded in producing ERG (231.0 mg/kg of media, which was 20 times higher than the wild type). Abbreviations: ERG: ergothioneine; HER: hercynine; Cys-HER: hercynylcysteine-sulfoxide; SAM: S-adenosylmethionine; SAH: S-adenosylhomocysteine; l-His: l-histidine; l-Cys: l-cysteine; LC-ESI-MS: liquid chromatography-electrospray ionization-mass spectrometry.

Entities:  

Keywords:  Aspergillus oryzae; Ergothioneine; Neurospora crassa; heterologous expression; molecular breeding

Mesh：

Substances：

Year:  2018        PMID： 30286703     DOI： 10.1080/09168451.2018.1527210

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  8 in total

1.  Toward more efficient ergothioneine production using the fungal ergothioneine biosynthetic pathway.

Authors:  Zhihui Chen; Yongzhi He; Xinyu Wu; Li Wang; Zhiyang Dong; Xiuzhen Chen
Journal:  Microb Cell Fact       Date:  2022-05-07       Impact factor: 6.352

Review 2.  Ergothioneine, Ovothiol A, and Selenoneine-Histidine-Derived, Biologically Significant, Trace Global Alkaloids.

Authors:  Geoffrey A Cordell; Sujeewa N S Lamahewage
Journal:  Molecules       Date:  2022-04-21       Impact factor: 4.927

3.  Engineering ergothioneine production in Yarrowia lipolytica.

Authors:  Steven A van der Hoek; Matej Rusnák; Irene Hjorth Jacobsen; José L Martínez; Douglas B Kell; Irina Borodina
Journal:  FEBS Lett       Date:  2021-12-05       Impact factor: 3.864

4.  Engineering the Yeast Saccharomyces cerevisiae for the Production of L-(+)-Ergothioneine.

Authors:  Steven A van der Hoek; Behrooz Darbani; Karolina E Zugaj; Bala Krishna Prabhala; Mathias Bernfried Biron; Milica Randelovic; Jacqueline B Medina; Douglas B Kell; Irina Borodina
Journal:  Front Bioeng Biotechnol       Date:  2019-10-11

5.  The biology of ergothioneine, an antioxidant nutraceutical.

Authors:  Irina Borodina; Louise C Kenny; Cathal M McCarthy; Kalaivani Paramasivan; Etheresia Pretorius; Timothy J Roberts; Steven A van der Hoek; Douglas B Kell
Journal:  Nutr Res Rev       Date:  2020-02-13       Impact factor: 7.800

6.  Enhancement of ergothioneine production by discovering and regulating its metabolic pathway in Cordyceps militaris.

Authors:  Bai-Xiong Chen; Ling-Na Xue; Tao Wei; Zhi-Wei Ye; Xue-Hai Li; Li-Qiong Guo; Jun-Fang Lin
Journal:  Microb Cell Fact       Date:  2022-08-23       Impact factor: 6.352

Review 7.  The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications.

Authors:  Douglas B Kell; Etheresia Pretorius
Journal:  Biochem J       Date:  2022-08-31       Impact factor: 3.766

8.  Successful biosynthesis of natural antioxidant ergothioneine in Saccharomyces cerevisiae required only two genes from Grifola frondosa.

Authors:  Ying-Hao Yu; Hong-Yu Pan; Li-Qiong Guo; Jun-Fang Lin; Han-Lu Liao; Hao-Ying Li
Journal:  Microb Cell Fact       Date:  2020-08-18       Impact factor: 5.328
  8 in total

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