Nicholas S Reed1,2, Jennifer A Deal2,3, Matthew G Huddle1, Joshua F Betz2,4, Bethany E Bailey5, Elyse J McGlumphy5, Allen O Eghrari5, S Amer Riazuddin5, Frank R Lin1,2,3, John D Gottsch5. 1. Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD. 2. Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, MD. 3. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. 4. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. 5. The Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD.
Abstract
Purpose: Although Fuchs corneal dystrophy (FCD) is considered an eye disease, a small number of studies have identified genes related to both FCD and hearing loss. Whether FCD is related to hearing loss is unknown. Method: This is a case-control study comparing pure-tone audiometry hearing thresholds in 180 patients with FCD from a hospital-based ophthalmology clinic with 2,575 population-based controls from a nationally representative survey, the National Health and Nutrition Examination Survey (from cycles 2005-06 and 2009-10). Generalized estimating equations were used to compare mean better-hearing ear thresholds in the 2 groups adjusted for age, sex, race, and noise exposure. Results: Patients with FCD had higher hearing thresholds (worse hearing) in lower frequencies (mean difference at 0.5 kHz = 3.49 dB HL) and lower hearing thresholds (better hearing) in higher frequencies (difference at 4 kHz = -4.25 dB HL) compared with population-based controls. Conclusion: In the first study to use objectively measured hearing, FCD was associated with poorer low-frequency and better high-frequency audiometric thresholds than population controls. Further studies are needed to characterize this relationship.
Purpose: Although Fuchs corneal dystrophy (FCD) is considered an eye disease, a small number of studies have identified genes related to both FCD and hearing loss. Whether FCD is related to hearing loss is unknown. Method: This is a case-control study comparing pure-tone audiometry hearing thresholds in 180 patients with FCD from a hospital-based ophthalmology clinic with 2,575 population-based controls from a nationally representative survey, the National Health and Nutrition Examination Survey (from cycles 2005-06 and 2009-10). Generalized estimating equations were used to compare mean better-hearing ear thresholds in the 2 groups adjusted for age, sex, race, and noise exposure. Results:Patients with FCD had higher hearing thresholds (worse hearing) in lower frequencies (mean difference at 0.5 kHz = 3.49 dB HL) and lower hearing thresholds (better hearing) in higher frequencies (difference at 4 kHz = -4.25 dB HL) compared with population-based controls. Conclusion: In the first study to use objectively measured hearing, FCD was associated with poorer low-frequency and better high-frequency audiometric thresholds than population controls. Further studies are needed to characterize this relationship.
Authors: Nicolas Grillet; Martin Schwander; Michael S Hildebrand; Anna Sczaniecka; Anand Kolatkar; Janice Velasco; Jennifer A Webster; Kimia Kahrizi; Hossein Najmabadi; William J Kimberling; Dietrich Stephan; Melanie Bahlo; Tim Wiltshire; Lisa M Tarantino; Peter Kuhn; Richard J H Smith; Ulrich Müller Journal: Am J Hum Genet Date: 2009-09 Impact factor: 11.025
Authors: Michael P Fautsch; Eric D Wieben; Keith H Baratz; Nihar Bhattacharyya; Amanda N Sadan; Nathaniel J Hafford-Tear; Stephen J Tuft; Alice E Davidson Journal: Prog Retin Eye Res Date: 2020-07-28 Impact factor: 21.198