| Literature DB >> 30286006 |
Peter Bedocs1,2, David L Evers3, Chester C Buckenmaier1,2.
Abstract
Admixtures of propofol-ketamine, propofol-ketamine-fentanyl, and propofol-ketamine-remifentanil were subjected to various clinically relevant conditions to study their chemical stability. A novel high-performance liquid chromatography-mass spectrometry method revealed no degradation of any compound by incubation at 37°C, constant mixing, or table-top storage for 6- and 24-hour time periods, except variable recovery of both propofol and fentanyl in the admixtures of propofol-ketamine-fentanyl suggesting possible degradation.Entities:
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Year: 2019 PMID： 30286006 DOI： 10.1213/ANE.0000000000003772
Source DB: PubMed Journal: Anesth Analg ISSN： 0003-2999 Impact factor: 5.108