Viviane Mancinelli Fonseca1, Priscila Soares Campos1, Thays Fernanda Certo1, Luana Taís de-Faria1, Priscila Bianchi Juliano2, Dennys Esper Cintra3, Richard Eloin Liebano4, Caroline da Silva5,6,7, Renata Michelini Guidi5,6,8, Estela Sant'Ana5,6. 1. a Dermatofunctional Aesthetics and Cosmetic Department , Ibramed Center for Education and Advanced Training (CEFAI) , Amparo , Brazil. 2. b Dermatofunctional Clinical Physiotherapist , Campinas , Brazil. 3. c Laboratory of Nutritional Genomics, School of Applied Sciences , University of Campinas (UNICAMP) , Campinas , Brazil. 4. d Physiotherapy Department , Federal University of São Carlos (UFSCar) , São Carlos-SP , Brazil. 5. e Researchers at Research, Development & Innovation Department IBRAMED , Ibramed Research Group (IRG) , Amparo , Brazil. 6. f Clinical Laboratory, Ibramed Center for Education and Advanced Training (CEFAI) , Amparo , Brazil. 7. g Department of Physical Education, Institute of Biosciences , São Paulo State University (UNESP) , Rio Claro , Brazil. 8. h Biomedical Engineering Department, Faculty of Electrical Engineering and Computing , University of Campinas (UNICAMP) , Campinas , Brazil.
Abstract
INTRODUCTION: In recent years, a new method focused ultrasound (FUS) has been used in the treatment of localized fat. The objectives of this work were to evaluate the efficacy and safety of the FUS in the treatment of abdominal subcutaneous fat. MATERIALS AND METHODS: Thirty-one healthy women were divided into two groups: G1 (N = 7), 6 sessions, 3 passes, once a week and G2 (N = 23), 10 sessions, 2 passes, twice a week. Outcome measures were reduction of circumference and fat thickness. Safety monitoring included laboratory testing (serum lipids profile and liver function tests) and adverse events were also assessed. Patient satisfaction and tolerance questionnaires were also applied. One patient underwent abdominoplasty and received a single session of FUS 24 h before surgery and a skin sample was collected for histological analysis. RESULTS: The results showed improvement in body contouring and reduction of the thickness of the fat layer observed by ultrasonography in both groups: G1 (P < 0.001) and G2 (P < 0.0001). The histology showed disrupted adipocytes and collapsed membranes 24 h after the FUS treatment. CONCLUSION: FUS represents an effective and safe treatment for reducing localized adipose tissue by adipocytolysis.
INTRODUCTION: In recent years, a new method focused ultrasound (FUS) has been used in the treatment of localized fat. The objectives of this work were to evaluate the efficacy and safety of the FUS in the treatment of abdominal subcutaneous fat. MATERIALS AND METHODS: Thirty-one healthy women were divided into two groups: G1 (N = 7), 6 sessions, 3 passes, once a week and G2 (N = 23), 10 sessions, 2 passes, twice a week. Outcome measures were reduction of circumference and fat thickness. Safety monitoring included laboratory testing (serum lipids profile and liver function tests) and adverse events were also assessed. Patient satisfaction and tolerance questionnaires were also applied. One patient underwent abdominoplasty and received a single session of FUS 24 h before surgery and a skin sample was collected for histological analysis. RESULTS: The results showed improvement in body contouring and reduction of the thickness of the fat layer observed by ultrasonography in both groups: G1 (P < 0.001) and G2 (P < 0.0001). The histology showed disrupted adipocytes and collapsed membranes 24 h after the FUS treatment. CONCLUSION:FUS represents an effective and safe treatment for reducing localized adipose tissue by adipocytolysis.