Literature DB >> 30284840

Recycling Catalyst as Reactant: A Sustainable Strategy To Improve Atom Efficiency of Organocatalytic Tandem Reactions.

Wen Wei1, Yuhai Tang1, Yan Zhou1, Ge Deng1, Ziyu Liu1, Jun Wu1, Yang Li1, Junjie Zhang1, Silong Xu1.   

Abstract

A sustainable strategy by internally recycling an organocatalyst as a reactant in a downstream reaction to improve the atom efficiency of organocatalytic tandem reactions is described. Specifically, a one-pot tandem Cloke-Wilson/Boulton-Katritzky reaction of cyclopropylketones with a hydroxylamine has been developed for the synthesis of fully substituted isoxazoles, in which the hydroxylamine serves as both an upstream catalyst and a downstream reactant.

Entities:  

Year:  2018        PMID： 30284840     DOI： 10.1021/acs.orglett.8b02898

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Synthesis of Spirobicyclic Pyrazoles by Intramolecular Dipolar Cycloadditions/[1s, 5s] Sigmatropic Rearrangements.

Authors:  Christine A Dimirjian; Marta Castiñeira Reis; Edward I Balmond; Nolan C Turman; Elys P Rodriguez; Michael J Di Maso; James C Fettinger; Dean J Tantillo; Jared T Shaw
Journal:  Org Lett       Date:  2019-09-05       Impact factor: 6.005

2.  Lewis-Acid-Catalyzed (3+2)-Cycloadditions of Donor-Acceptor Cyclopropanes with Thioketenes.

Authors:  Grzegorz Mlostoń; Mateusz Kowalczyk; André U Augustin; Peter G Jones; Daniel B Werz
Journal:  European J Org Chem       Date:  2021-08-25

3.  A facile metal-free one-flask synthesis of multi-substituted furans via a BF3·Et2O mediated formal [4 + 1] reaction of 3-chloro-3-phenyldiazirines and α,β-alkenyl ketones.

Authors:  Zixin Zhang; Aimin Huang; Lin Ma; Jian-Hua Xu; Min Zhang
Journal:  RSC Adv       Date:  2022-05-18       Impact factor: 4.036

4.  Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste.

Authors:  Bo-Shuai Mu; Xiao-Yuan Cui; Xing-Ping Zeng; Jin-Sheng Yu; Jian Zhou
Journal:  Nat Commun       Date:  2021-04-08       Impact factor: 14.919
  4 in total

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