Literature DB >> 30284488

The diverse role of TIGAR in cellular homeostasis and cancer.

Ji Geng1, Xiao Yuan2, Mingzhen Wei1, Junchao Wu1, Zheng-Hong Qin1.   

Abstract

TP53-induced glycolysis and apoptosis regulator (TIGAR) is a p53 target protein that plays critical roles in glycolysis and redox balance. Accumulating evidence shows that TIGAR is highly expressed in cancer. TIGAR redirects glycolysis and promotes carcinoma growth by providing metabolic intermediates and reductive power derived from pentose phosphate pathway (PPP). The expression of TIGAR in cancer is positively associated with chemotherapy resistance, suggesting that TIGAR could be a novel therapeutic target. In this review, we briefly presented the function of TIGAR in metabolic homeostasis in normal and cancer cells. Finally, we discussed the future directions of TIGAR research in cancer.

Entities:  

Keywords:  Cancer; TIGAR; glycolysis; oxidative stress; pentose phosphate pathway

Mesh：

Substances：

Year:  2018        PMID： 30284488     DOI： 10.1080/10715762.2018.1489133

Source DB:  PubMed          Journal:  Free Radic Res        ISSN： 1029-2470


  10 in total

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