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Literature DB >> 30284136

Research Progress on the Relationship Between Acute Pancreatitis and Calcium Overload in Acinar Cells.

Siqing Feng¹, Qiongqiong Wei¹, Qing Hu², Xiaomei Huang¹, Xi Zhou², Gang Luo², Mingming Deng³, Muhan Lü⁴.

Abstract

Acute pancreatitis is a human disease with multiple causes that leads to autodigestion of the pancreas. There is sufficient evidence to support the key role of sustained increase in cytosolic calcium concentrations in the early pathogenesis of the disease. To clarify the mechanism of maintaining calcium homeostasis in the cell and pathological processes caused by calcium overload would help to research directly targeted therapeutic agents. We will specifically review the following: intracellular calcium homeostasis and regulation, the occurrence of calcium overload in acinar cells, the role of calcium overload in the pathogenesis of AP, the treatment strategy proposed for calcium overload.

Entities: Chemical Disease Species

Keywords: Acinar cells; Calcium; Pancreatitis; Pathophysiology; Therapy

Mesh：

Substances：
Calcium

Year: 2018 PMID： 30284136 DOI： 10.1007/s10620-018-5297-8

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

107 in total

Review 1. Antioxidant therapy in acute pancreatitis: experimental and clinical evidence.

Authors: Thilo Hackert; Jens Werner
Journal: Antioxid Redox Signal Date: 2011-08-11 Impact factor: 8.401

2. Lasting inhibition of receptor-mediated calcium oscillations in pancreatic acini by neutrophil respiratory burst--a novel mechanism for secretory blockade in acute pancreatitis?

Authors: Hui Yuan Liang; Zhi Min Song; Zong Jie Cui
Journal: Biochem Biophys Res Commun Date: 2013-06-29 Impact factor: 3.575

3. Expression of the platelet-activating factor receptor in human spermatozoa: differences in messenger ribonucleic acid content and protein distribution between normal and abnormal spermatozoa.

Authors: W E Roudebush; M D Wild; E H Maguire
Journal: Fertil Steril Date: 2000-05 Impact factor: 7.329

4. Acute hypercalcemia causes acute pancreatitis and ectopic trypsinogen activation in the rat.

Authors: K Mithöfer; C Fernández-del Castillo; T W Frick; K B Lewandrowski; D W Rattner; A L Warshaw
Journal: Gastroenterology Date: 1995-07 Impact factor: 22.682

Review 5. Pancreatitis and hyperparathyroidism.

Authors: A Sitges-Serra; M Alonso; C de Lecea; P F Gores; D E Sutherland
Journal: Br J Surg Date: 1988-02 Impact factor: 6.939

6. Hyperparathyroidism and pancreatitis. Chance or a causal association?

Authors: M A Bess; A J Edis; J A van Heerden
Journal: JAMA Date: 1980-01-18 Impact factor: 56.272

7. Acute pancreatitis in primary hyperparathyroidism: a population-based study.

Authors: Teck Kim Khoo; Santhi Swaroop Vege; Haitham S Abu-Lebdeh; Euijung Ryu; Sarah Nadeem; Robert A Wermers
Journal: J Clin Endocrinol Metab Date: 2009-03-24 Impact factor: 5.958

Review 8. Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases.

Authors: Sudheer K Mantena; Adrienne L King; Kelly K Andringa; Heather B Eccleston; Shannon M Bailey
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9. Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.

Authors: Julia V Gerasimenko; György Lur; Mark W Sherwood; Etsuko Ebisui; Alexei V Tepikin; Katsuhiko Mikoshiba; Oleg V Gerasimenko; Ole H Petersen
Journal: Proc Natl Acad Sci U S A Date: 2009-06-15 Impact factor: 11.205

10. Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors.

Authors: Julia V Gerasimenko; Sarah E Flowerdew; Svetlana G Voronina; Tatiana K Sukhomlin; Alexei V Tepikin; Ole H Petersen; Oleg V Gerasimenko
Journal: J Biol Chem Date: 2006-10-30 Impact factor: 5.157

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2. The changes of triacylglycerol and inflammatory factors during dialysis treatment of hypertriglyceridemia during pregnancy and analysis of nursing countermeasure.

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Journal: Am J Transl Res Date: 2021-06-15 Impact factor: 4.060

Review 3. A narrative review of acute pancreatitis and its diagnosis, pathogenetic mechanism, and management.

Authors: Zhi Zheng; Yi-Xuan Ding; Yuan-Xu Qu; Feng Cao; Fei Li
Journal: Ann Transl Med Date: 2021-01

4. Gelsolin impairs barrier function in pancreatic ductal epithelial cells by actin filament depolymerization in hypertriglyceridemia-induced pancreatitis in vitro.

Authors: Hui-Ying Yang; Zhi-Hai Liang; Jin-Lian Xie; Qing Wu; Ying-Ying Qin; Shi-Yu Zhang; Guo-Du Tang
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5. Establishment of Early Multi-Indicator Prediction Models of Moderately Severe Acute Pancreatitis and Severe Acute Pancreatitis.

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Journal: Gastroenterol Res Pract Date: 2022-04-04 Impact factor: 2.260