| Literature DB >> 30282753 |
Huiwen Zheng1, Jingjing Wang1, Bingxiang Li1, Lei Guo1, Heng Li1, Jie Song1, Zening Yang1, Hongzhe Li1, Haitao Fan1, Xing Huang1, Haiting Long1, Chen Cheng1, Manman Chu1, Zhanlong He1, Wenhai Yu1, Jiaqi Li1, You Gao1, Ruotong Ning1, Nan Li1, Jinxi Yang1, Qiongwen Wu1, Haijing Shi1, Ming Sun2, Longding Liu2.
Abstract
Enterovirus D68 (EV-D68) belongs to the picornavirus family and was first isolated in CA, USA, in 1962. EV-D68 can cause severe cranial nerve system damage such as flaccid paralysis and acute respiratory diseases such as pneumonia. There are currently no efficient therapeutic methods or effective prophylactics. In this study, we isolated the mAb A6-1 from an EV-D68-infected rhesus macaque (Macaca mulatta) and found that the Ab provided effective protection in EV-D68 intranasally infected suckling mice. We observed that A6-1 bound to the DE loop of EV-D68 VP1 and interfered with the interaction between the EV-D68 virus and α2,6-linked sialic acids of the host cell. The production of A6-1 and its Ab properties present a bridging study for EV-D68 vaccine design and provide a tool for analyzing the process by which Abs can inhibit EV-D68 infection.Entities:
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Year: 2018 PMID： 30282753 DOI： 10.4049/jimmunol.1800655
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422