Ngozi Charity Chidi-Egboka1, Nancy E Briggs2, Isabelle Jalbert3, Blanka Golebiowski1. 1. School of Optometry and Vision Science, UNSW, Sydney, NSW, 2052, Australia. 2. Stats Central, Markwainwright Analytical Centre, UNSW, Sydney, Australia. 3. School of Optometry and Vision Science, UNSW, Sydney, NSW, 2052, Australia. Electronic address: i.jalbert@unsw.edu.au.
Abstract
PURPOSE: A review of ocular surface and meta-analysis of tear stability (tear break up time, TBUT) and tear secretion (Schirmer test) values in healthy children was conducted. METHODS: Articles published between 1996 and 2017 indexed on MEDLINE, PubMed, Embase, Scopus and Google Scholar were retrieved using defined search terms. Statistical analysis (including sensitivity analysis and meta-regression) was performed. RESULTS: 23 studies were summarised (5,291 participants; neonates (0-29 days), infants (1 month - 1 year) or children (1-18 years) and a meta-analysis conducted using 15 eligible studies (1,077 participants). The combined mean TBUT in children was 14.64 seconds (s) (95% CI, 11.64, 17.64) and 21.76 s (95% CI, 20.43, 23.09) for sodium fluorescein TBUT and non-invasive TBUT respectively (NIBUT). The combined mean NIBUT was 32.5 s (95% CI, 31.78-33.22) in neonates. The combined mean Schirmer I with and without anesthesia were 16.26 mm/5 min (95% CI, 13.17, 19.36) and 29.30 mm/5 min (95% CI, 27.65, 30.96) in children and 9.36 mm/5 min (95% CI, 6.54, 12.18) and 17.63 mm/5 min (95% CI, 12.03, 23.23) in neonates. Meta-regression showed a significantly lower TBUT in children from studies conducted in Asia (p = 0.004). CONCLUSION: There is paucity of data on ocular surface variables in healthy children, making it difficult to draw valid comparisons with adult values.
PURPOSE: A review of ocular surface and meta-analysis of tear stability (tear break up time, TBUT) and tear secretion (Schirmer test) values in healthy children was conducted. METHODS: Articles published between 1996 and 2017 indexed on MEDLINE, PubMed, Embase, Scopus and Google Scholar were retrieved using defined search terms. Statistical analysis (including sensitivity analysis and meta-regression) was performed. RESULTS: 23 studies were summarised (5,291 participants; neonates (0-29 days), infants (1 month - 1 year) or children (1-18 years) and a meta-analysis conducted using 15 eligible studies (1,077 participants). The combined mean TBUT in children was 14.64 seconds (s) (95% CI, 11.64, 17.64) and 21.76 s (95% CI, 20.43, 23.09) for sodium fluorescein TBUT and non-invasive TBUT respectively (NIBUT). The combined mean NIBUT was 32.5 s (95% CI, 31.78-33.22) in neonates. The combined mean Schirmer I with and without anesthesia were 16.26 mm/5 min (95% CI, 13.17, 19.36) and 29.30 mm/5 min (95% CI, 27.65, 30.96) in children and 9.36 mm/5 min (95% CI, 6.54, 12.18) and 17.63 mm/5 min (95% CI, 12.03, 23.23) in neonates. Meta-regression showed a significantly lower TBUT in children from studies conducted in Asia (p = 0.004). CONCLUSION: There is paucity of data on ocular surface variables in healthy children, making it difficult to draw valid comparisons with adult values.
Authors: Lin Li; Jing Zhang; Moxin Chen; Xue Li; Qiao Chu; Run Jiang; Zhihao Liu; Lili Zhang; Jun Shi; Yi Wang; Weizhong Zhu; Jian Chen; Pengcheng Xun; Jibo Zhou Journal: Front Public Health Date: 2021-12-01
Authors: Jane E Nieto; Israel Casanova; Juan Carlos Serna-Ojeda; Enrique O Graue-Hernández; Guillermo Quintana; Alberto Salazar; María C Jiménez-Martinez Journal: Int J Mol Sci Date: 2020-10-23 Impact factor: 5.923