Literature DB >> 30282046

Fatty Acid Oxidation in Macrophages and T Cells: Time for Reassessment?

Jan Van den Bossche1, Gerritje J W van der Windt2.   

Abstract

Previous immunometabolism research using the CPT1 inhibitor etomoxir suggests that long-chain fatty acid oxidation (LC-FAO) supports IL-4-driven alternative macrophage activation (M(IL-4)) and regulates memory and regulatory T cell formation. Divakaruni et al. (2018) and Raud et al. (2018) now report that LC-FAO is largely dispensable for these processes.
Copyright © 2018 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 30282046     DOI： 10.1016/j.cmet.2018.09.018

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  20 in total

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9.  Isotope Tracing Untargeted Metabolomics Reveals Macrophage Polarization-State-Specific Metabolic Coordination across Intracellular Compartments.

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Review 10.  Immunometabolic Checkpoints of Treg Dynamics: Adaptation to Microenvironmental Opportunities and Challenges.

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