OBJECTIVE: In recent years metagenomic analysis has become more accessible for the characterization of biological specimens. There has been an important increase of studies using this technique for subgingival human samples. To date, there are no updated systematic reviews on the relationship between oral microbiota and periodontal disease. The aim of the present systematic review was to update data about studies concerning the influences of changes in oral microbiota composition on the periodontal status in human subjects. MATERIALS AND METHODS: An electronic search was conducted in four databases (MEDLINE, Scopus, CENTRAL and Web of Science) for articles published in English from January 2014 to April 2018. In vitro or animal studies, case reports, case series, retrospective studies, review articles, abstracts and discussions were excluded. Also, studies that evaluated less than 5 microbial species, only viruses or already known periodontal pathogens were excluded. Two independent researches selected the studies and extracted the data. The quality of evidence was assessed as high, moderate or low for each microorganism. RESULTS: Eight studies and three additional publications recovered from the bibliography search of the selected articles were included in the review. The Bacteria domain was the main detected among the others and it included 53 species. The review confirmed the presence of recognized periodontal pathogens such as the members of the red complex but also identified, with high weight of evidence, the presence of new pathogens. CONCLUSIONS: The results of this systematic review support high evidence for the association of 3 new species/genera with the etiology of periodontitis. Future investigations on the actual role of these new pathogens in the onset and progression of the disease are needed.
OBJECTIVE: In recent years metagenomic analysis has become more accessible for the characterization of biological specimens. There has been an important increase of studies using this technique for subgingival human samples. To date, there are no updated systematic reviews on the relationship between oral microbiota and periodontal disease. The aim of the present systematic review was to update data about studies concerning the influences of changes in oral microbiota composition on the periodontal status in human subjects. MATERIALS AND METHODS: An electronic search was conducted in four databases (MEDLINE, Scopus, CENTRAL and Web of Science) for articles published in English from January 2014 to April 2018. In vitro or animal studies, case reports, case series, retrospective studies, review articles, abstracts and discussions were excluded. Also, studies that evaluated less than 5 microbial species, only viruses or already known periodontal pathogens were excluded. Two independent researches selected the studies and extracted the data. The quality of evidence was assessed as high, moderate or low for each microorganism. RESULTS: Eight studies and three additional publications recovered from the bibliography search of the selected articles were included in the review. The Bacteria domain was the main detected among the others and it included 53 species. The review confirmed the presence of recognized periodontal pathogens such as the members of the red complex but also identified, with high weight of evidence, the presence of new pathogens. CONCLUSIONS: The results of this systematic review support high evidence for the association of 3 new species/genera with the etiology of periodontitis. Future investigations on the actual role of these new pathogens in the onset and progression of the disease are needed.
Authors: R J Genco; M J LaMonte; D I McSkimming; M J Buck; L Li; K M Hovey; C A Andrews; Y Sun; M Tsompana; W Zheng; H R Banack; V Murugaiyan; J Wactawski-Wende Journal: J Dent Res Date: 2019-08 Impact factor: 6.116
Authors: Paolo Boffano; Alberto Pau; Camilla Dosio; Muhammad Ruslin; Tymour Forouzanfar; Tanía Rodríguez-Santamarta; Juan Carlos de Vicente; Marko Tarle; Emil Dediol; Petia Pechalova; Nikolai Pavlov; Hristo Daskalov; Iva Doykova; Kadri Kelemith; Tiia Tamme; Andrey Kopchak; Romanova Anna Yu; Pierre Corre; Helios Bertin; Maeva Bourry; Pierre Guyonvarc'h; Zoran Jezdić; Vitomir S Konstantinovic; Thomas Starch-Jensen; Matteo Brucoli Journal: Oral Maxillofac Surg Date: 2021-09-09
Authors: Michael J LaMonte; Christopher A Andrews; Kathleen M Hovey; Michael J Buck; Lu Li; Daniel I McSkimming; Hailey R Banack; Jane Rotterman; Yijun Sun; Keith L Kirkwood; Jean Wactawski-Wende Journal: J Periodontol Date: 2020-11-03 Impact factor: 6.993
Authors: Gabriele Cervino; Marco Cicciù; Antonio Biondi; Salvatore Bocchieri; Alan Scott Herford; Luigi Laino; Luca Fiorillo Journal: Antibiotics (Basel) Date: 2019-05-02