Literature DB >> 30280156

CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation.

Takeshi Yamada1, Shouta Miki, Lu Ni, Kazuhiko Nakatani.   

Abstract

A new DNA binding small molecule, NCD-CC is reported. NCD-CC has a NCD domain, which recognizes the G-G mismatch in a CGG/CGG triad, and a cysteinylcystein (CC) moiety. Dimerization of NCD-CC through intermolecular disulfide bond formation was accelerated in the presence of CGG repeat DNA.

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Year:  2018        PMID: 30280156     DOI: 10.1039/c8cc06757k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  1 in total

1.  Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats.

Authors:  Sanjukta Mukherjee; Leszek Błaszczyk; Wojciech Rypniewski; Christoph Falschlunger; Ronald Micura; Asako Murata; Chikara Dohno; Kazuhiko Nakatani; Agnieszka Kiliszek
Journal:  Nucleic Acids Res       Date:  2019-11-18       Impact factor: 16.971

  1 in total

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