Literature DB >> 30279931

Brugada syndrome unmasked by malaria-induced fever.

Abdullah Cader1, Sheldon M Singh2, Mohammad I Zia3.   

Abstract

Brugada syndrome is typically an autosomal dominant genetic disorder with variable expression, characterized by three specific electrocardiogram (ECG) patterns. While Type I Brugada ECG pattern is used as a classic marker for the disease, it is generally masked from ECG except in special cases such as malaria-induced fever. This vignette highlights a unique clinical scenario that can lead to the unmasking of Brugada type 1 pattern. <Learning objective: Brugada syndrome is associated with ventricular arrhythmias which if left untreated can result in syncope or premature death. Early intervention involving lifestyle modifications and recommendation of implantable defibrillator is based on diagnosis. Yet, Brugada syndrome is hard to detect from an electrocardiogram (ECG) alone. Still there are certain circumstances that unmask the Brugada syndrome ECG pattern. This case report provides one clinical scenario leading to the incidental unmasking of Brugada syndrome.>.

Entities:  

Keywords:  Brugada syndrome; Cardiac disease; Genetics

Year:  2018        PMID: 30279931      PMCID: PMC6149654          DOI: 10.1016/j.jccase.2018.06.002

Source DB:  PubMed          Journal:  J Cardiol Cases        ISSN: 1878-5409


  4 in total

1.  Fever increases the risk for cardiac arrest in the Brugada syndrome.

Authors:  Ahmad S Amin; Paola G Meregalli; Abdennasser Bardai; Arthur A M Wilde; Hanno L Tan
Journal:  Ann Intern Med       Date:  2008-08-05       Impact factor: 25.391

2.  "Brugada" syndrome: clinical data and suggested pathophysiological mechanism.

Authors:  M Alings; A Wilde
Journal:  Circulation       Date:  1999-02-09       Impact factor: 29.690

3.  Cardiac electrophysiological substrate underlying the ECG phenotype and electrogram abnormalities in Brugada syndrome patients.

Authors:  Junjie Zhang; Frédéric Sacher; Kurt Hoffmayer; Thomas O'Hara; Maria Strom; Phillip Cuculich; Jennifer Silva; Daniel Cooper; Mitchell Faddis; Mélèze Hocini; Michel Haïssaguerre; Melvin Scheinman; Yoram Rudy
Journal:  Circulation       Date:  2015-03-25       Impact factor: 29.690

4.  Long-term prognosis of patients diagnosed with Brugada syndrome: Results from the FINGER Brugada Syndrome Registry.

Authors:  V Probst; C Veltmann; L Eckardt; P G Meregalli; F Gaita; H L Tan; D Babuty; F Sacher; C Giustetto; E Schulze-Bahr; M Borggrefe; M Haissaguerre; P Mabo; H Le Marec; C Wolpert; A A M Wilde
Journal:  Circulation       Date:  2010-01-25       Impact factor: 29.690

  4 in total

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